Browsing by Subject "Virulence"
Now showing items 1-16 of 16
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Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.
(PLoS Genet, 2014-04)Cryptococcus neoformans is a pathogenic basidiomycetous yeast responsible for more than 600,000 deaths each year. It occurs as two serotypes (A and D) representing two varieties (i.e. grubii and neoformans, respectively). ... -
Complete genome sequencing and analysis of six enterovirus 71 strains with different clinical phenotypes.
(Virol J, 2013-04-11)BACKGROUND: Hand, foot and mouth diseases (HFMD) caused by enterovirus 71(EV71) presents a broad spectrum of clinical manifestations ranging from mild febrile disease to fatal neurolocal disease. However, the mechanism of ... -
Contribution of bacterial outer membrane vesicles to innate bacterial defense.
(BMC Microbiol, 2011-12-01)BACKGROUND: Outer membrane vesicles (OMVs) are constitutively produced by Gram-negative bacteria throughout growth and have proposed roles in virulence, inflammation, and the response to envelope stress. Here we investigate ... -
Cryptococcus Neoformans Interactions with Surfactant Proteins: Implications for Innate Pulmonary Immunity
(2009)Concurrent with the global escalation of the AIDS pandemic, cryptococcal infections are increasing and are of significant medical importance. Although improvements in antifungal therapy have advanced the treatment ... -
Cryptococcus neoformans transcriptional regulation of the host-pathogen interface
(2013)<italic>Cryptococcus neoformans </italic>is a human fungal pathogen that is also ubiquitous in the environment. To cause disease inside a human host, <italic>C. neoformans</italic> must be able to sense and respond to a ... -
Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin.
(Microbiology, 2010-03)The isoleucine and valine biosynthetic enzyme acetolactate synthase (Ilv2p) is an attractive antifungal drug target, since the isoleucine and valine biosynthetic pathway is not present in mammals, Saccharomyces cerevisiae ... -
Dual impact of elevated temperature on plant defence and bacterial virulence in Arabidopsis.
(Nature communications, 2017-11-27)Environmental conditions profoundly affect plant disease development; however, the underlying molecular bases are not well understood. Here we show that elevated temperature significantly increases the susceptibility of ... -
High-throughput identification of chemical inhibitors of E. coli Group 2 capsule biogenesis as anti-virulence agents.
(PLoS One, 2010-07-19)Rising antibiotic resistance among Escherichia coli, the leading cause of urinary tract infections (UTIs), has placed a new focus on molecular pathogenesis studies, aiming to identify new therapeutic targets. Anti-virulence ... -
Interaction of Cryptococcus neoformans Rim101 and protein kinase A regulates capsule.
(PLoS Pathog, 2010-02-19)Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within various tissues in order to establish a human infection. We have identified the C. neoformans Rim101 transcription factor, a highly conserved ... -
Live Imaging of Host-Parasite Interactions in a Zebrafish Infection Model Reveals Cryptococcal Determinants of Virulence and Central Nervous System Invasion.
(MBio, 2015-09-29)UNLABELLED: The human fungal pathogen Cryptococcus neoformans is capable of infecting a broad range of hosts, from invertebrates like amoebas and nematodes to standard vertebrate models such as mice and rabbits. Here we ... -
Potential associations between severity of infection and the presence of virulence-associated genes in clinical strains of Staphylococcus aureus.
(PLoS One, 2011-04-26)BACKGROUND: The clinical spectrum of Staphylococcus aureus infection ranges from asymptomatic nasal carriage to osteomyelitis, infective endocarditis (IE) and death. In this study, we evaluate potential association between ... -
The Chlamydia trachomatis Protease CPAF Regulates Secreted Bacterial Effectors and Host Proteins Essential to Virulence
(2011)<italic>Chlamydia<italic> <italic>trachomatis<italic> remains a highly relevant clinical pathogen as it is the causative agent of the most commonly reported sexually transmitted disease in the western hemisphere, and the ... -
The pandemic Escherichia coli sequence type 131 strain is acquired even in the absence of antibiotic exposure.
(PLoS pathogens, 2019-12-19) -
Unisexual Reproduction in Cryptococcus: Evolutionary Implications, Virulence and RNA Silencing
(2013)Sexual development enables microbial pathogens to purge deleterious mutations from the genome and drives genetic diversity in the population. <italic>Cryptococcus neoformans</italic> is a human fungal pathogen with a defined ... -
Unveiling Protein Kinase A Targets in Cryptococcus neoformans Capsule Formation.
(MBio, 2016-02-09)The protein kinase A (PKA) signal transduction pathway has been associated with pathogenesis in many fungal species. Geddes and colleagues [mBio 7(1):e01862-15, 2016, doi:10.1128/mBio.01862-15] used quantitative proteomics ... -
Variation in chromosome copy number influences the virulence of Cryptococcus neoformans and occurs in isolates from AIDS patients.
(BMC Genomics, 2011-10-27)BACKGROUND: The adaptation of pathogenic fungi to the host environment via large-scale genomic changes is a poorly characterized phenomenon. Cryptococcus neoformans is the leading cause of fungal meningoencephalitis in HIV/AIDS ...
