Now showing items 1-10 of 10

    • Catch me if you can: the link between autophagy and viruses. 

      Lennemann, Nicholas J; Coyne, Carolyn B (PLoS pathogens, 2015-03-26)
    • Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test. 

      Tsalik, Ephraim L; Henao, Ricardo; Montgomery, Jesse L; Nawrocki, Jeff W; Aydin, Mert; Lydon, Emily C; Ko, Emily R; ... (24 authors) (Critical care medicine, 2021-10)
      <h4>Objectives</h4>Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and ...
    • Etiology of severe non-malaria febrile illness in Northern Tanzania: a prospective cohort study. 

      Crump, John A; Morrissey, Anne B; Nicholson, William L; Massung, Robert F; Stoddard, Robyn A; Galloway, Renee L; Ooi, Eng Eong; ... (12 authors) (PLoS Negl Trop Dis, 2013)
      INTRODUCTION: The syndrome of fever is a commonly presenting complaint among persons seeking healthcare in low-resource areas, yet the public health community has not approached fever in a comprehensive manner. In many areas, ...
    • Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection. 

      Ko, Emily R; Henao, Ricardo; Frankey, Katherine; Petzold, Elizabeth A; Isner, Pamela D; Jaehne, Anja K; Allen, Nakia; ... (36 authors) (JAMA network open, 2022-04)
      <h4>Importance</h4>Bacterial and viral causes of acute respiratory illness (ARI) are difficult to clinically distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host gene expression-based ...
    • Rates of coalescence for common epidemiological models at equilibrium. 

      Koelle, Katia; Rasmussen, David A (J R Soc Interface, 2012-05-07)
      Coalescent theory provides a mathematical framework for quantitatively interpreting gene genealogies. With the increased availability of molecular sequence data, disease ecologists now regularly apply this body of theory ...
    • Systematic comparison of published host gene expression signatures for bacterial/viral discrimination. 

      Bodkin, Nicholas; Ross, Melissa; McClain, Micah T; Ko, Emily R; Woods, Christopher W; Ginsburg, Geoffrey S; Henao, Ricardo; ... (8 authors) (Genome medicine, 2022-02-21)
      <h4>Background</h4>Measuring host gene expression is a promising diagnostic strategy to discriminate bacterial and viral infections. Multiple signatures of varying size, complexity, and target populations have been described. ...
    • The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood. 

      Tsalik, Ephraim L; Fiorino, Cassandra; Aqeel, Ammara; Liu, Yiling; Henao, Ricardo; Ko, Emily R; Burke, Thomas W; ... (18 authors) (Frontiers in immunology, 2021-01)
      Viruses cause a wide spectrum of clinical disease, the majority being acute respiratory infections (ARI). In most cases, ARI symptoms are similar for different viruses although severity can be variable. The objective of ...
    • Type III Interferons in Antiviral Defenses at Barrier Surfaces. 

      Wells, Alexandra I; Coyne, Carolyn B (Trends in immunology, 2018-10)
      Barrier surfaces such as the epithelium lining the respiratory and gastrointestinal (GI) tracts, the endothelium comprising the blood-brain barrier (BBB), and placental trophoblasts provide key physical and immunological ...
    • Validation of a Host Gene Expression Test for Bacterial/Viral Discrimination in Immunocompromised Hosts. 

      Mahle, Rachael E; Suchindran, Sunil; Henao, Ricardo; Steinbrink, Julie M; Burke, Thomas W; McClain, Micah T; Ginsburg, Geoffrey S; ... (9 authors) (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-08)
      <h4>Background</h4>Host gene expression has emerged as a complementary strategy to pathogen detection tests for the discrimination of bacterial and viral infection. The impact of immunocompromise on host-response tests remains ...
    • Viral phylodynamics. 

      Volz, EM; Koelle, K; Bedford, T (PLoS Comput Biol, 2013)
      Viral phylodynamics is defined as the study of how epidemiological, immunological, and evolutionary processes act and potentially interact to shape viralphylogenies. Since the coining of the term in 2004, research on viral ...