Now showing items 1-8 of 8

    • African and Asian strains of Zika virus differ in their ability to infect and lyse primitive human placental trophoblast. 

      Sheridan, Megan A; Balaraman, Velmurugan; Schust, Danny J; Ezashi, Toshihiko; Roberts, R Michael; Franz, Alexander WE (PloS one, 2018-01)
      Zika virus (ZIKV) drew worldwide attention when a recent epidemic was linked to fetal microcephaly. Here we used human embryonic stem cell derived trophoblasts as a model for primitive placental trophoblast to test the hypothesis ...
    • Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling. 

      Bayer, Avraham; Lennemann, Nicholas J; Ouyang, Yingshi; Sadovsky, Elena; Sheridan, Megan A; Roberts, R Michael; Coyne, Carolyn B; ... (8 authors) (Placenta, 2018-01)
      INTRODUCTION:Cultured primary human trophoblasts (PHT), derived from term placentas, are relatively resistant to infection by diverse viruses. The resistance can be conferred to non-trophoblastic cells by pre-exposing them ...
    • Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages. 

      Zimmerman, Matthew G; Quicke, Kendra M; O'Neal, Justin T; Arora, Nitin; Machiah, Deepa; Priyamvada, Lalita; Kauffman, Robert C; ... (17 authors) (Cell host & microbe, 2018-11)
      Zika virus (ZIKV), which emerged in regions endemic to dengue virus (DENV), is vertically transmitted and results in adverse pregnancy outcomes. Antibodies to DENV can cross-react with ZIKV, but whether these antibodies ...
    • Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections. 

      Aid, Malika; Ram, Daniel R; Bosinger, Steven E; Barouch, Dan H; Reeves, R Keith (Frontiers in cellular and infection microbiology, 2020-01)
      Natural killer (NK) cells are crucial regulators of antiviral and anti-tumor immune responses. Although in humans some NK cell transcriptional programs are relatively well-established, NK cell transcriptional networks in ...
    • Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero. 

      Jagger, Brett W; Miner, Jonathan J; Cao, Bin; Arora, Nitin; Smith, Amber M; Kovacs, Attila; Mysorekar, Indira U; ... (9 authors) (Cell host & microbe, 2017-09)
      Although Zika virus (ZIKV)-induced congenital disease occurs more frequently during early stages of pregnancy, its basis remains undefined. Using established type I interferon (IFN)-deficient mouse models of ZIKV transmission ...
    • RIPK3: Beyond Necroptosis. 

      Evans, Azia S; Coyne, Carolyn B (Immunity, 2019-01)
      In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production ...
    • STING'ing Zika virus in neurons. 

      Coyne, Carolyn B (Nature microbiology, 2018-09)
      Studies in Drosophila reveal that the insect homologue of the stimulator of interferon genes (STING) exerts antiviral activity against Zika virus infection in the fly brain through the induction of autophagy, providing key ...
    • Vaccines in 2017: Closing in on a Zika virus vaccine. 

      Diamond, Michael S; Coyne, Carolyn B (Nature reviews. Immunology, 2018-02)