Browsing by Subject "aging"
Now showing items 1-20 of 37
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Age Differences in Striatal Delay Sensitivity during Intertemporal Choice in Healthy Adults.
(Front Neurosci, 2011)Intertemporal choices are a ubiquitous class of decisions that involve selecting between outcomes available at different times in the future. We investigated the neural systems supporting intertemporal decisions in healthy ... -
Age Differences in Suggestibility Following Semantic Illusions: The Role of Prior Knowledge
(2014)In the face of declines in memory related to specific events, people maintain intact general knowledge into very old age. Older adults often use this knowledge to support their remembering. Semantic illusions involve situations ... -
Age-related Differences in the Neural Mechanisms of Episodic Memory: Representational and Network Analyses
(2023)Advanced age is associated with substantial changes in the brain. These changes can be attributed to many difference sources, such as detrimental effects of aging, brain’s compensatory responses to such negative effects, ... -
An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection.
(Neuron, 2018-01-03)Infections have been identified as possible risk factors for aging-related neurodegenerative diseases, but it remains unclear whether infection-related immune molecules have a causative role in neurodegeneration during aging. ... -
An Assessment of Information & Assistance Services For Seniors Needing Long-term Care in North Carolina: What has changed and what comes next for the Aging Network?
(2011-04-22)Policy Question: How should North Carolina’s Aging Network provide information and assistance services so that all older adults (and their caregivers) looking for long-term care receive appropriate guidance? Introduction: ... -
Association Between Comorbidities and Outcomes in Heart Failure Patients With and Without an Implantable Cardioverter-Defibrillator for Primary Prevention.
(J Am Heart Assoc, 2015-08-06)BACKGROUND: Implantable cardioverter-defibrillator (ICD) therapy is associated with improved outcomes in patients with heart failure (HF), but whether this association holds among older patients with multiple comorbid illnesses ... -
Cerebral White Matter Mediation of Age-Related Differences in Picture Naming Across Adulthood.
(Neurobiology of language (Cambridge, Mass.), 2022-03)As people age, one of the most common complaints is difficulty with word retrieval. A wealth of behavioral research confirms such age-related language production deficits, yet the structural neural differences that relate ... -
Constant mortality and fertility over age in Hydra.
(Proc Natl Acad Sci U S A, 2015-12-22)Senescence, the increase in mortality and decline in fertility with age after maturity, was thought to be inevitable for all multicellular species capable of repeated breeding. Recent theoretical advances and compilations ... -
Dancing in the Squares
(2015)“Guangchangwu,” or what is literally translated as “square-dancing,” is a form of public dance that has been exceedingly popular, albeit controversial, in China over recent years. Most of the participants are elderly women ... -
Developing Predictors of Long-Term Adherence to Exercise Among Older Veterans and Spouses.
(Journal of applied gerontology : the official journal of the Southern Gerontological Society, 2019-09-21)Behavior change theory was used to explore predictors of long-term adherence (≥2 years) to exercise. A retrospective analysis of data from participants (N = 97) who reached a 6-month follow-up, which served as the baseline, ... -
Features of imagination that contribute to value-based decision making
(2022)Humans make a variety of choices every day. Some of these choices are pretty mundane like whether to eat pancakes or oatmeal for breakfast. Others cost a little more, have a little bit of a longer impact, like which vacuum ... -
Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age.
(Hum Brain Mapp, 2017-04)We conducted functional magnetic resonance imaging (fMRI) with a visual search paradigm to test the hypothesis that aging is associated with increased frontoparietal involvement in both target detection and bottom-up attentional ... -
Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.
(Aging (Albany NY), 2017-03-04)Recent research has proposed that GIT2 (G protein-coupled receptor kinase interacting protein 2) acts as an integrator of the aging process through regulation of 'neurometabolic' integrity. One of the commonly accepted hallmarks ... -
GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.
(Front Endocrinol (Lausanne), 2015)Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system ... -
Glioblastoma as an age-related neurological disorder in adults.
(Neuro-oncology advances, 2021-01)<h4>Background</h4>Advanced age is a major risk factor for the development of many diseases including those affecting the central nervous system. Wild-type isocitrate dehydrogenase glioblastoma (IDHwt GBM) is the most common ... -
Heuristics for Truth Across the Lifespan
(2018)Misleading claims surround us – we encounter them in news stories, advertising campaigns, and political propaganda. How do people separate facts from fiction? Decades of work implicate fluency, or subjective ease. Repeated ... -
Interactions between oxidative stress and insulin/IGF-1 signaling for starvation resistance in Caenorhabditis elegans
(2019-04-22)Reactive oxygen species (ROS) are a natural byproduct of metabolism with roles in cell signaling and homeostasis but also generate oxidative stress. Past research demonstrates that ROS are a major factor in pathological ... -
Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.
(Front Syst Neurosci, 2017)Each year over 16 million older Americans undergo general anesthesia for surgery, and up to 40% develop postoperative delirium and/or cognitive dysfunction (POCD). Delirium and POCD are each associated with decreased quality ... -
Invited Commentary: Integrating Genomics and Social Epidemiology-Analysis of Late-Life Low Socioeconomic Status and the Conserved Transcriptional Response to Adversity.
(Am J Epidemiol, 2017-09-01)Socially disadvantaged children face increased morbidity and mortality as they age. Understanding mechanisms through which social disadvantage becomes biologically embedded and devising measurements that can track this embedding ... -
Is chronic asthma associated with shorter leukocyte telomere length at midlife?
(Am J Respir Crit Care Med, 2014-08-15)RATIONALE: Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. OBJECTIVES: To test ...
