Browsing by Subject "androgen receptor"
Now showing items 1-4 of 4
-
Integrated Chromatin Analyses Offer Insights Into Trans-factor Function In Cancer Cell Lines
(2012)Understanding the mechanisms whereby the sequence of the human genome is interpreted into diverse cellular phenotypes is a critical endeavor in modern biology. A major determinant of cellular phenotype is the spatial and ... -
Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases.
(Rare Dis, 2014)Non-cell autonomous degeneration has arisen as an important mechanism in neurodegenerative disorders. Using a novel line of BAC androgen receptor (AR) transgenic mice with a floxed transgene (BAC fxAR121), we uncovered a ... -
Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.
(Oncotarget, 2016-08-02)Treatment with androgen-targeted therapies can induce upregulation of epithelial plasticity pathways. Epithelial plasticity is known to be important for metastatic dissemination and therapeutic resistance. The goal of this ... -
Targeting Histone Deacetylases in Advanced Prostate Cancer
(2015)The androgen receptor (AR) signaling axis is a well-established therapeutic target in prostate cancer, due to its central role in tumor maintenance and progression. Although patients respond initially to androgen deprivation ...
