Browsing by Subject "angiogenesis"
Now showing items 1-11 of 11
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Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo.
(Proc Natl Acad Sci U S A, 2014-04-15)Tissue-engineered skeletal muscle can serve as a physiological model of natural muscle and a potential therapeutic vehicle for rapid repair of severe muscle loss and injury. Here, we describe a platform for engineering and ... -
CD45+ Cells Present Within Mesenchymal Stem Cell Populations Affect Network Formation of Blood-Derived Endothelial Outgrowth Cells.
(Biores Open Access, 2015)Mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) represent promising cell sources for angiogenic therapies. There are, however, conflicting reports regarding the ability of MSCs to support network formation ... -
Cell Wall Lipids Promoting Host Angiogenesis During Mycobacterial Infection
(2018)Mycobacterial infection leads to the formation of characteristic immune cell aggregates called granulomas. In humans and animal models, tuberculous granuloma formation is accompanied by dramatic remodeling of host vasculature ... -
Cellular Signaling Mechanisms Underlying the Angiogenic Response to Mycobacterial Infection
(2022)Pathological angiogenesis is a widespread biological phenomenon that influences the progression of various diseases, including autoimmune conditions, cancers, and microbial infections. One infection in particular, tuberculosis, ... -
Characterizing the Role of the Previously Undescribed Protein Caskin2 in Vascular Biology
(2016)Maintenance of vascular homeostasis is an active process that is dependent on continuous signaling by the quiescent endothelial cells (ECs) that line mature vessels. Defects in vascular homeostasis contribute to numerous ... -
Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.
(Proceedings of the National Academy of Sciences of the United States of America, 2018-02)The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ... -
Interstitial engraftment of adipose-derived stem cells into an acellular dermal matrix results in improved inward angiogenesis and tissue incorporation.
(J Biomed Mater Res A, 2013-10)Acellular dermal matrices (ADM) are commonly used in reconstructive procedures and rely on host cell invasion to become incorporated into host tissues. We investigated different approaches to adipose-derived stem cells (ASCs) ... -
Light-Inducible Gene Regulation in Mammalian Cells
(2015)The growing complexity of scientific research demands further development of advanced gene regulation systems. For instance, the ultimate goal of tissue engineering is to develop constructs that functionally and morphologically ... -
Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
(Int J Nanomedicine, 2009)A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. ... -
The Effect of Porous Poly-L-Lactic Acid Coatings on Tissue Response and Subsequent Glucose Sensor Performance
(2009)Efforts to create a reliable, long–term implantable glucose sensor have been stymied by the effects of the foreign body response and wound healing that introduce delayed response times as well as unpredictable sensor performance. ... -
The Role of Angiopoietin-2 in Signaling Through the Endothelial Receptor Tyrosine Kinase Tie1
(2010)A functioning vasculature is critical for the supply of nutrients to other systems as well as a host of physiologic and pathologic processes. Vascular development and maintenance are tightly regulated by a number of signaling ...
