Browsing by Subject "antifungal"
Now showing items 1-7 of 7
-
Characterizing the Physiochemical Properties of Copper Chelating Agents: an Effort Towards Understanding their Antifungal Activity
(2015)An increase in drug-resistant infections and the paucity of new antibiotics present a major world health problem. Cryptococcus neoformans (C. neoformans) is an opportunistic fungal pathogen responsible for life-threatening ... -
!Development of small molecule therapeutics against anti-infectious and anti-cancer drug resistance via structure-based drug design
(2022)!Drug discovery typically involves structure-based drug design based on three-dimensional protein structures and hit/lead compound identification and optimization. Herein, this technique was used to overcome several obstacles ... -
Insight into How the Coordination Environment of Cu Influences Chemical and Biological Activity of the Antifungal Peptide Histatin-5
(2019)The histidine-rich salivary peptides of the histatin family are known to bind copper (Cu) and other metal ions in vitro, but the details of these interactions are poorly understood and their implications on in vivo antifungal ... -
Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei.
(Antimicrobial Agents and Chemotherapy, 2019-02)Amphotericin B deoxycholate (DAmB) is a first-line agent for the initial treatment of talaromycosis. However, little is known about the population pharmacokinetics and pharmacodynamics of DAmB for talaromycosis. Pharmacokinetic ... -
Printing amphotericin B on microneedles using matrix-assisted pulsed laser evaporation.
(International journal of bioprinting, 2017-01)Transdermal delivery of amphotericin B, a pharmacological agent with activity against fungi and parasitic protozoa, is a challenge since amphotericin B exhibits poor solubility in aqueous solutions at physiologic pH values. ... -
Role of isavuconazole in the treatment of invasive fungal infections.
(Ther Clin Risk Manag, 2016)Despite recent advances in both diagnosis and prevention, the incidence of invasive fungal infections continues to rise. Available antifungal agents to treat invasive fungal infections include polyenes, triazoles, ... -
Sexual Reproduction and Signal Transduction in the Candida Species Complex
(2008-08-07)Although the majority of the population carries Candida spp as normal components of their microflora, these species are important human pathogens that have the ability to cause disease under conditions of immunosuppression ...
