Browsing by Subject "apoptosis"
Now showing items 1-17 of 17
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Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.
(Int J Cancer, 2015-11-15)Single nucleotide polymorphisms (SNPs) in the promoter region of FAS and FASLG may alter their transcriptional activity. Thus, we determined the associations between four FAS and FASLG promoter variants (FAS1377G>A, rs2234767; ... -
Autophagy in Metabolism, Cell Death, and Leukemogenesis
(2011)Tissue homeostasis is controlled by the availability of growth factors, which sustain exogenous nutrient uptake and prevent apoptosis. Cancer cells, however, can express constitutively active oncogenic kinases such as BCR-Abl ... -
Characterization of Blast-Induced Activation of Human Immune Cells
(2012)Blast related injuries have become a common occurrence among soldiers and civilians serving in Iraq and Afghanistan, and minor traumatic brain injuries associated with such incidents have increased correspondingly. Advances ... -
Dysregulation of Cell Survival in Diffuse Large B Cell Lymphoma: Mechanisms and Therapeutic Targets.
(Frontiers in Oncology, 2019-01)Diffuse large B cell lymphoma (DLBCL) is the most common type of lymphoma worldwide, representing 30-40% of non-Hodgkin lymphomas, and is clinically aggressive. Although more than half of patients with DLBCL are cured by ... -
Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.
(Elife, 2017-04-20)Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV expresses viral oncogenes that promote cell growth and inhibit the apoptotic response to uncontrolled proliferation. The EBV oncoprotein ... -
Evaluation of LMP-420: A Novel, Nontoxic Drug with Anti-Inflammatory Properties and Therapeutic Potential for CLL
(2012)B-cell chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Although treatment of this disease has advanced considerably over the past decade, CLL remains incurable with current chemotherapeutics. ... -
Functional screening to define apoptosis-inducing precision cancer therapies
(2018)Cancer is a diverse set of diseases characterized by genetic and epigenetic alterations that permit growth across diverse environmental contexts. The last decade has led to an explosion of sequencing efforts to define the ... -
Mono- or Double-Site Phosphorylation Distinctly Regulates the Proapoptotic Function of Bax
(2010)Bax is the major multidomain proapoptotic molecule that is required for apoptosis. It has been reported that phosphorylation of Bax at serine(S) 163 or S184 activates or inactivates its proapoptotic function, respectively. ... -
Mucosal Associated Invariant T (MAIT) Cell Responses Differ by Sex in COVID-19.
(Med (New York, N.Y.), 2021-04-13)Sexual dimorphisms in immune responses contribute to coronavirus disease 2019 (COVID-19) outcomes, yet the mechanisms governing this disparity remain incompletely understood. We carried out sex-balanced sampling of peripheral ... -
Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation.
(Int J Chron Obstruct Pulmon Dis, 2011)Patients with chronic obstructive pulmonary disease (COPD) exhibit dominant features of chronic bronchitis, emphysema, and/or asthma, with a common phenotype of airflow obstruction. COPD pulmonary physiology reflects the ... -
Regulation of Apoptosis Following Mitochondrial Cytochrome c Release
(2010)Many pro-apoptotic signals trigger mitochondrial cytochrome c release, leading to caspase activation and ultimate cellular breakdown. Cell survival pathways, including the mitogen-activated protein kinase (MAPK) cascade, ... -
Regulation of Mitochondrial Dynamics during Apoptosis and the Cell Cycle
(2010)Homeostatic maintenance of cellular mitochondria requires a dynamic balance between fission and fusion, and disruptions in this balance have been implicated in multiple pathological conditions, including Charcot-Marie-Tooth, ... -
The human UDP-galactose 4'-epimerase (GALE) is required for cell-surface glycome structure and function.
(The Journal of biological chemistry, 2019-12-09)Glycan biosynthesis relies on nucleotidesugars (NS), abundant metabolites that serve as monosaccharide donors for glycosyltransferases. In vivo, signal-dependent fluctuations in NS levels are required to maintain normal ... -
The Role of c-FLIP in the Regulation of Apoptosis, Necroptosis and Autophagy in T Lymphocytes
(2013)To maintain homeostasis, T lymphocytes die through caspase–dependent apoptosis. However, blockage of caspase activity in T lymphocytes does not increase cell survival. The loss of caspase 8 activity leads to programmed ... -
The role of TRIM39 in cell cycle and apoptosis
(2013)Within individual cells, the opposing processes of proliferation and apoptosis are precisely regulated. When this regulatory balance is interrupted, cells may become abnormal or even transformed. Understanding how to reverse ... -
The Roles of the Bcl-2 Family Proteins in T Lymphocyte Development and Homeostasis
(2011)Throughout their development in the thymus and during their maintenance and the immunological response in the periphery, T cells rely on the regulation of classical apoptotic pathways to promote cell survival or death. Several ... -
Understanding the Cellular Response to Cytosolic Cytochrome c
(2010)Cytosolic cytochrome c promotes apoptosis by triggering caspase activation. In healthy cells cytochrome c localizes to mitochondria, where it participates in the electron transport chain. Apoptotic stimuli induce permeabilization ...
