Now showing items 1-3 of 3

    • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 

      Boyce, Michael; Yi, Caroline H; Sogah, Dodzie K; Degterev, Alexei; Christofferson, Dana E; Yuan, Junying (The Journal of cell biology, 2007-11-12)
      Apoptosis is an evolutionally conserved cellular suicide mechanism that can be activated in response to a variety of stressful stimuli. Increasing evidence suggests that apoptotic regulation relies on specialized cell death ...
    • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 

      Chao, Nelson J; Chute, JP; Deoliviera, D; Doan, Phuong Linh; Fixsen, Emma; Harris, Jeffrey R; Helms, K; ... (12 authors) (Nat Med, 2013-03)
      The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of ...
    • The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. 

      Huang, NJ; Zhang, L; Tang, W; Chen, C; Yang, CS; Kornbluth, S (J Cell Biol, 2012-04-30)
      Proapoptotic Bcl-2 family members, such as Bax, promote release of cytochrome c from mitochondria, leading to caspase activation and cell death. It was previously reported that modulator of apoptosis protein 1 (MOAP-1), ...