Browsing by Subject "biomaterials"
Now showing items 1-7 of 7
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Bioengineered Approaches to Prevent Hypertrophic Scar Contraction
(2016)Burn injuries in the United States account for over one million hospital admissions per year, with treatment estimated at four billion dollars. Of severe burn patients, 30-90% will develop hypertrophic scars (HSc). Current ... -
Bioengineering Microporous Annealed Particle Scaffolds to Recruit Neural Progenitor Stem Cells and Promote Angiogenesis in the Stroke Core
(2022)There remains a significant gap in the need for regenerative therapies for stroke compared to what is currently available. An ideal therapy would be one that stimulates the formation of new tissue with the ability to regain ... -
Biomimetic Composite Scaffolds for the Functional Tissue Engineering of Articular Cartilage
(2009)Articular cartilage is the connective tissue that lines the ends of long bones in diarthrodial joints, providing a low-friction load-bearing surface that can withstand a lifetime of loading cycles under normal conditions. ... -
Development of Genetically Encoded Zwitterionic Polypeptides for Drug Delivery
(2019)The clinical utility of many peptide, protein and small molecule drugs is limited by their short in-vivo ¬half-life. To address this limitation, we report a new class of biomaterials that have a long plasma circulation time. ... -
Improved Posterolateral Lumbar Spinal Fusion Using a Biomimetic, Nanocomposite Scaffold Augmented by Autologous Platelet-Rich Plasma.
(Frontiers in bioengineering and biotechnology, 2021-01)Remodeling of the human bony skeleton is constantly occurring with up to 10% annual bone volume turnover from osteoclastic and osteoblastic activity. A shift toward resorption can result in osteoporosis and pathologic fractures, ... -
LOcal Void Analysis of MAP scaffolds (LOVAMAP)
(2022)Our lab designs hydrogel microparticles (HMPs) that are interlinked to form microporous annealed particle (MAP) scaffolds for wound healing applications. The therapeutic effects of MAP are attributed, in part, to the void ... -
The Immunoengineering Toolbox: A Set of Thermoresponsive Biopolymers for Sustained Delivery of Cancer Immunotherapies
(2022)Therapeutic cancer vaccines have the potential to revolutionize cancer treatment by providing systemic control of both local and metastatic malignancies. However, stimulating antitumor immune responses in patients with cancer ...
