Browsing by Subject "breast cancer"
Now showing items 1-20 of 32
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Application of Phylogenetic Analysis in Cancer Evolution
(2018)Cancer is a major threat to human health and results in 1 in 6 deaths globally. Despite an extraordinary amount of effort and money spent, eradication or control of advanced disease has not yet been achieved. Understanding ... -
Automatic Planning of Whole Breast Radiation Therapy Using Machine Learning Models.
(Frontiers in Oncology, 2019-01)Purpose: To develop an automatic treatment planning system for whole breast radiation therapy (WBRT) based on two intensity-modulated tangential fields, enabling near-real-time planning. Methods and Materials: A total of ... -
Distinct Receptor Tyrosine Kinase Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer.
(J Biol Chem, 2017-01-13)Targeted inhibitors of the human epidermal growth factor receptor 2 (HER2), such as trastuzumab and lapatinib, are among the first examples of molecularly targeted cancer therapy and have proven largely effective for the ... -
Dual-emissive, oxygen-sensing boron nanoparticles quantify oxygen consumption rate in breast cancer cells.
(Journal of biomedical optics, 2020-11)<h4>Significance</h4>Decreasing the oxygen consumption rate (OCR) of tumor cells is a powerful method for ameliorating tumor hypoxia. However, quantifying the change in OCR is challenging in complex experimental ... -
Ectodomain Shedding of TGF-beta Receptors: Role in Signaling and Breast Cancer Biology
(2013)The transforming growth factor beta (TGF-beta) signaling pathway is a critical regulator of multiple biological processes that are involved in cancer progression, such as proliferation, migration, invasion and metastasis. ... -
Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients.
(J Pers Med, 2021-10-19)A family health history-based risk assessment is particularly valuable for guiding cancer screening and treatment strategies, yet an optimal implementation depends upon end-users' values and needs. This is not only true ... -
Exploring the functional consequences of whole-genome duplication in tumor progression
(2021)Whole-genome duplication (WGD) generates polyploid cells possessing more than two copies of the genome. These events commonly occur during the evolution of human tumors across tissue types and mutational drivers, affecting ... -
Extracellular Hsp90 is Actively Trafficked and Internalized in Breast Cancer Cells
(2016)Despite its ubiquitous abundance, Hsp90 inhibitors have shown promise in anti-cancer clinical trials, suggesting that Hsp90 inhibitors selectively target tumor cells while exhibiting minimal effects in normal cells. Extracellular ... -
Genomic Signatures of Disease and Environmental Exposure in the Peripheral Blood
(2011)My thesis research has centered on the concept of the peripheral blood cell (PBC) as an indicator of disease and environmental exposure. The PBC is not only easily accessible and constantly replenished, but it provides a ... -
Goal-Driven Beam Setting Optimization for Whole-Breast Radiation Therapy.
(Technology in cancer research & treatment, 2019-01)PURPOSE:To develop an automated optimization program to generate optimal beam settings for whole-breast radiation therapy driven by clinically oriented goals. MATERIALS AND METHODS:Forty patients were retrospectively included ... -
Harnessing Optical Imaging for Assessing Metabolic Reprogramming in Breast Cancer
(2020)According to the World Health Organization, there were over 2 million new breast cancer cases in 2018. This number is projected to steadily increase year after year. American Cancer Society projections for 2020 list the ... -
Injectable Ablation Technique for Cancer Treatment Across Clinical Settings
(2023)Cancer treatment regimens often include surgery, radiation, and chemotherapy. Though the World Health Organization (WHO) Essential Medicines List includes many globally accessible chemotherapies, surgery and radiation are ... -
Interrogating Transcriptional and Translational Networks that Promote Metastatic Colonization of the Brain
(2021)Human epidermal growth factor receptor 2-positive (HER2+) and triple-negative breast cancer patients often present with brain metastasis. HER2-targeted therapies have not been successful to treat brain metastases in part ... -
Investigating the Efficacy of a Lovingkindness Meditation Intervention for Patients Undergoing Breast Cancer Surgery: A Randomized Controlled Pilot Study
(2015)Breast cancer is the most common type of cancer among women in the United States. Despite more women undergoing treatment and increased survival rates, many women continue to suffer from emotional distress and physical ... -
Investigation of the role of environmental polycyclic aromatic hydrocarbon endocrine disrupting chemicals in breast cancer
(2021)Cancers are a complex set of related diseases with wide ranging etiologies, and humans are exposed to a milieu of environmental exposures that may contribute to disease development. Breast cancer in particular is a complex ... -
Lactate Metabolism in Cancer Cell Lines
(2013)Pathophysiologic lactate accumulation is characteristic of solid tumors and has been associated with metastases and poor overall survival in cancer patients. In recent years, there has been a resurgence of interest in tumor ... -
Large-Scale Analysis of Protein Folding and Stability Changes Associated with Breast Cancer
(2018)Proteomic methods for disease state characterization and biomarker discovery have traditionally utilized quantitative mass spectrometry methods to identify proteins with altered expression levels in disease states. Unfortunately, ... -
Metabolic vulnerability in HER2-positive Breast Cancer
(2018)The human epidermal growth factor receptor 2, or HER2, is overexpressed in 20-30% breast cancer patients and is associated with aggressive disease. Therapies targeting HER2, including monoclonal antibodies (trastuzumab and ... -
Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
(Int J Nanomedicine, 2009)A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. ... -
Molecular Mechanisms Governing the Untoward Tumor Growth Promoting Effects of Selective Estrogen Receptor Modulators
(2018)Luminal breast cancer is among the most prevalent diseases in women in the United States and worldwide. Historically, luminal cancers have been effectively managed with treatments that alter the availability of estrogens ...
