Browsing by Subject "cancer"
Now showing items 1-20 of 30
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A Stochastic Spatial Model for Tumor Growth
(2014-04-29)Evolutionary game theory can be used to study the interactions of different cell phenotypes and describe tumor population dynamics. Instead of killing tumor cells, clinical treatment could aim to change the nature of the ... -
Analysis of the Transport Behavior of Escherichia Coli in a Novel Three-Dimensional In Vitro Tumor Model
(2010)Three-dimensional (3D) tumor models aim to reduce the need for animal models for drug and gene delivery studies. However, many models are not conducive to environmental manipulation and may not be easily adapted for <italic>in ... -
Antigen-Loaded Monocytes as a Novel Cancer Vaccine
(2017)Dendritic cells (DC) have been the key elements in developing cancer vaccines to induce potent T cell responses to eradicate tumors. However, the common approach adopted in clinical trials using ex vivo generated DC loaded ... -
Autophagy in Metabolism, Cell Death, and Leukemogenesis
(2011)Tissue homeostasis is controlled by the availability of growth factors, which sustain exogenous nutrient uptake and prevent apoptosis. Cancer cells, however, can express constitutively active oncogenic kinases such as BCR-Abl ... -
Cellular Reprogramming in Response to Viral Infection and Oncogenic Transformation
(2021)In this dissertation, I reported several cellular reprogramming mechanisms in response to different factors, such as viral infection and oncogenic transformation, by utilizing molecular biology and high-throughput sequencing ... -
Design, Synthesis, and Biological Characterization of Largazole Analogues
(2016)Histone deacetylases (HDACs) have been shown to play key roles in tumorigenesis, andhave been validated as effective enzyme target for cancer treatment. Largazole, a marine naturalproduct isolated from the cyanobacterium ... -
Determining the Role of DDX3X in Normal and Malignant Germinal Center B Cells
(2019)Burkitt lymphoma (BL) is an aggressive germinal center (GC) B cell derived lymphoma. BL accounts for 40% of pediatric lymphoma cases in the United States and over half of all pediatric malignancies in Sub Saharan Africa. ... -
Development of a Nutritional Screening Tool for Pediatric Cancer Patients in Uganda and Tanzania: An Exploratory Analysis
(2020)Background: Nutrition is a key determinant of pediatric cancer patient outcomes in sub-Saharan Africa. Accurately identifying pediatric cancer patients at risk of malnutrition remains a challenge. There is a need ... -
Discovery and Characterization of a Novel Fatty Acid Synthase Inhibitor with Antineoplastic Activity against Breast Cancer
(2016)During oncogenesis, cancer cells go through metabolic reprogramming to maintain their high growth rates and adapt to changes in the microenvironment and the lack of essential nutrients. Several types of cancer are dependent ... -
EBV BART MicroRNAs Target Pro-apoptotic and Anti-Wnt Signaling Genes to Promote Cell Survival and Proliferation
(2015)Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus which chronically infects >95% of the global population, and can give rise to a number of malignancies in B cells and epithelial cells. In EBV latently infected ... -
Exploiting Metabolic Vulnerabilities In Solid Tumors Treated With ABL Kinase Allosteric Inhibitors
(2021)Metastases are common and devastating complications linked to ~90% of cancer deaths. Therapy-resistance is a major challenge for the treatment of cancer cell metastasis as metastatic cells metabolically rewire to survive ... -
Exploring the Interface Between Therapeutically Relevant Polymers and the Immune System
(2019)In order to ameliorate current maladies, improvements to medicaments and treatment regimens are required. Our lab seeks to translate findings from the laboratory bench to the patient bedside using two approaches: 1) the ... -
Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.
(IUBMB life, 2021-05-07)The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins involved in correcting and clearing misfolded proteins ... -
Influence of Delay on Cancer Stage among Patients with Kaposi Sarcoma in Uganda
(2012)The incidence of Kaposi sarcoma (KS) has increased rapidly since the advent of the HIV epidemic. Although patient outcomes have improved significantly in high-income countries after the introduction of highly-active ... -
Knowledge-Based IMRT Treatment Planning for Bilateral Head and Neck Cancer
(2013)Intensity-modulated radiotherapy (IMRT) remains the standard of care for external beam radiation therapy for head and neck cancers. Planning for IMRT requires a trial-and-error approach that is completely dependent on planner ... -
Links Between Communication and Relationship Satisfaction Among Patients With Cancer and Their Spouses: Results of a Fourteen-Day Smartphone-Based Ecological Momentary Assessment Study.
(Frontiers in psychology, 2018-01)Cancer treatment poses significant challenges not just for those diagnosed with the disease but also for their intimate partners. Evidence suggests that couples' communication plays a major role in the adjustment of both ... -
Metabolic Targeting of Cancer Cells: Two Molecular Mechanisms Involving Glucose Metabolism
(2009)Selective therapeutic targeting of tumors requires identification of differences between the homeostatic requirements of cancer and host cells. One such difference is the manner in which cancer cells acquire energy. Cancer ... -
Modeling the Dynamics of Cancerous Tumors in Vivo
(2015-10-26)A key area of interest in cancer research is understanding tumor dynamics, so that tumor growth can be predicted more easily and treated more reliably. We explored in vivo tumor dynamics starting from simple exponential ... -
Molecular Characterization of Genetic and Epigenetic Alterations in Gliomas
(2012)Glioma development and progression are driven by complex genetic alterations, including point mutations and gain or loss of genomic copy number, as well as epigenetic aberrations, including DNA methylation and histone ... -
Oncogenic KRAS Expression and Signaling
(2012)RAS is a small GTPase that helps to convert extracellular cues into intracellular actions. It is the most commonly mutated oncogene and is found in an active mutant form in 90% of pancreatic cancers. Therefore, study of ...
