ALERT: This system is being upgraded on Tuesday December 12. It will not be available for use for several hours that day while the upgrade is in progress. Deposits to DukeSpace will be disabled on Monday December 11, so no new items are to be added to the repository while the upgrade is in progress. Everything should be back to normal by the end of day, December 12.

Now showing items 1-4 of 4

    • Cell-cycle control of cell polarity in yeast. 

      Moran, Kyle D; Kang, Hui; Araujo, Ana V; Zyla, Trevin R; Saito, Koji; Tsygankov, Denis; Lew, Daniel J (The Journal of cell biology, 2019-01)
      In many cells, morphogenetic events are coordinated with the cell cycle by cyclin-dependent kinases (CDKs). For example, many mammalian cells display extended morphologies during interphase but round up into more spherical ...
    • How cells determine the number of polarity sites. 

      Chiou, Jian-Geng; Moran, Kyle D; Lew, Daniel J (eLife, 2021-04-26)
      The diversity of cell morphologies arises, in part, through regulation of cell polarity by Rho-family GTPases. A poorly understood but fundamental question concerns the regulatory mechanisms by which different cells generate ...
    • Mechanistic insights into actin-driven polarity site movement in yeast. 

      Ghose, Debraj; Lew, Daniel (Molecular biology of the cell, 2020-05)
      Directed cell growth or migration are critical for the development and function of many eukaryotic cells. These cells develop a dynamic "front" (also called "polarity site") that can change direction. Polarity establishment ...
    • Ratiometric GPCR signaling enables directional sensing in yeast. 

      Henderson, Nicholas T; Pablo, Michael; Ghose, Debraj; Clark-Cotton, Manuella R; Zyla, Trevin R; Nolen, James; Elston, Timothy C; ... (8 authors) (PLoS biology, 2019-10-17)
      Accurate detection of extracellular chemical gradients is essential for many cellular behaviors. Gradient sensing is challenging for small cells, which can experience little difference in ligand concentrations on the up-gradient ...