Browsing by Subject "chromatin"
Now showing items 1-11 of 11
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Chromatin Accessibility Dynamics Underlying Development and Disease
(2015)Despite a largely static DNA sequence, our genomes are incredibly malleable. Comparative studies of chromatin features between different cell types, tissues, and species have revealed tremendous differences in how the genome ... -
Chromatin Dynamics and Regulation of the Helicase During Replication Initiation
(2021)DNA replication is an intricate process within eukaryotic cells that must be precisely executed to preserve genetic information. This process begins at multiple start sites, or origins of replication, along each chromosome ... -
Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.
(Oncotarget, 2018-07-27)Mutation of the APC gene occurs in a high percentage of colorectal tumors and is a central event driving tumor initiation in the large intestine. The APC protein performs multiple tumor suppressor functions including negative ... -
Defining the Role of the Histone Methyltransferase, PR-Set7, in Maintaining the Genome Integrity of Drosophila Melanogaster
(2016)The complete and faithful duplication of the genome is essential to ensure normal cell division and organismal development. Eukaryotic DNA replication is initiated at multiple sites termed origins of replication that are ... -
Editing the Neuronal Genome: a CRISPR View of Chromatin Regulation in Neuronal Development, Function, and Plasticity.
(Yale J Biol Med, 2016-12)The dynamic orchestration of gene expression is crucial for the proper differentiation, function, and adaptation of cells. In the brain, transcriptional regulation underlies the incredible diversity of neuronal cell types ... -
Establishment and Regulation of Silenced Chromatin in Saccharomyces Cerevisiae
(2009)Heterochromatin, or condensed chromatin, is a transcriptionally repressive form of chromatin that occurs in many eukaryotic organisms. At its natural locations, heterochromatin is thought to play important roles in genome ... -
Gene Duplication and the Evolution of Silenced Chromatin in Yeasts
(2010)In <italic>Saccharomyces cerevisiae</italic>, proper maintenance of haploid cell identity requires the SIR complex to mediate the silenced chromatin found at the cryptic mating-type loci, <italic>HML</italic> and ... -
Glucocorticoids Preferentially Influence Expression of Nucleoskeletal Actin Network and Cell Adhesive Proteins in Human Trabecular Meshwork Cells.
(Frontiers in cell and developmental biology, 2022-01)Clinical use of glucocorticoids is associated with increased intraocular pressure (IOP), a major risk factor for glaucoma. Glucocorticoids have been reported to induce changes in actin cytoskeletal organization, cell adhesion, ... -
RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin.
(Elife, 2017-08-01)Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. ... -
Studies on Human Chromatin Using High-Throughput DNaseI Sequencing
(2009)Cis-elements govern the key step of transcription to regulate gene expression within a cell. Identification of utilized elements within a particular cell line will help further our understanding of individual and cumulative ... -
Variable histone modifications at the A(vy) metastable epiallele
(2010)The ability of environmental factors to shape health and disease involves epigenetic mechanisms that mediate gene-environment interactions. Metastable epiallele genes are variably expressed in genetically identical individuals ...
