Browsing by Subject "clinical trials"
Now showing items 1-10 of 10
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A Decade On: Systematic Review of ClinicalTrials.gov Infectious Disease Trials, 2007-2017.
(Open forum infectious diseases, 2019-06)Background:Registration of interventional trials of Food and Drug Administration-regulated drug and biological products and devices became a legal requirement in 2007; the vast majority of these trials are registered in ... -
Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015.
(J Am Heart Assoc, 2015-11-05)BACKGROUND: A 1.5-day interactive forum was convened to discuss critical issues in the acquisition, analysis, and sharing of data in the field of cardiovascular and stroke science. The discussion will serve as the foundation ... -
An innovative educational program for addressing health disparities in translational cancer research.
(Journal of clinical and translational science, 2020-11)North Carolina Central University (NCCU) and Duke Cancer Institute implemented an NCI-funded Translational Cancer Disparities Research Partnership to enhance translational cancer research, increase the pool of underrepresented ... -
Characteristics of pediatric pulmonary hypertension trials registered on ClinicalTrials.gov.
(Pulm Circ, 2017-04)The investigation of pediatric pulmonary hypertension (PH) drugs has been identified as a high priority by the United States National Institutes of Health (NIH). Studying pediatric PH is challenging due to the rare ... -
Development and evaluation of a novel training program to build study staff skills in equitable and inclusive engagement, recruitment, and retention of clinical research participants.
(Journal of clinical and translational science, 2022-01)<h4>Background</h4>Adequate equitable recruitment of underrepresented groups in clinical research and trials is a national problem and remains a daunting challenge to translating research discoveries into effective healthcare ... -
Factors influencing longitudinal changes of circulating liver enzyme concentrations in subjects randomized to placebo in four clinical trials.
(American journal of physiology. Gastrointestinal and liver physiology, 2019-03)Liver enzyme concentrations are measured as safety end points in clinical trials to detect drug-related hepatotoxicity, but little is known about the epidemiology of these biomarkers in subjects without hepatic dysfunction ... -
Interfaces between Bayesian and Frequentist Multiplte Testing
(2015)This thesis investigates frequentist properties of Bayesian multiple testing procedures in a variety of scenarios and depicts the asymptotic behaviors of Bayesian methods. Both Bayesian and frequentist approaches to multiplicity ... -
NRG Oncology Survey on Practice and Technology Use in SRT and SBRT Delivery.
(Frontiers in oncology, 2020-01)<h4>Purpose</h4>To assess stereotactic radiotherapy (SRT)/stereotactic body radiotherapy (SBRT) practices by polling clinics participating in multi-institutional clinical trials.<h4>Methods</h4>The NRG Oncology Medical Physics ... -
Sibling umbilical cord blood infusion is safe in young children with cerebral palsy.
(Stem cells translational medicine, 2021-09)Preclinical and early phase clinical studies suggest that an appropriately dosed umbilical cord blood (CB) infusion has the potential to help improve motor function in young children with cerebral palsy (CP). As many children ... -
The Challenge of Community Representation.
(J Empir Res Hum Res Ethics, 2016-10)Although community advisory boards (CABs) are widely used in clinical research, there is limited data regarding their composition and structure, especially in Africa. Our research provides the first qualitative study of ...
