Browsing by Subject "colorectal cancer"

Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.

Hankey, William; Chen, Zhong; Bergman, Maxwell J; Fernandez, Max O; Hancioglu, Baris; Lan, Xun; Jegga, Anil G; ... (12 authors) (Oncotarget, 2018-07-27)

Mutation of the APC gene occurs in a high percentage of colorectal tumors and is a central event driving tumor initiation in the large intestine. The APC protein performs multiple tumor suppressor functions including negative ...

Living with long-term consequences: Experience of follow-up care and support needs among Asian long-term colorectal cancer survivors.

Yoon, Sungwon; Chua, Teck Beng; Tan, Iain Beehuat; Matchar, David; Ong, Marcus Eng Hock; Tan, Emile (Psycho-oncology, 2020-10)

<h4>Objectives</h4>This study aimed to provide an in-depth exploration of follow-up care experiences and supportive care needs in long-term colorectal cancer (CRC) survivors within multiethnic Asian communities.<h4>Metho...

Utility of a molecular prescreening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials.

Overman, MJ; Morris, V; Kee, B; Fogelman, D; Xiao, L; Eng, C; Dasari, A; ... (22 authors) (Ann Oncol, 2016-06)

BACKGROUND: Incorporation of multiple enrichment biomarkers into prospective clinical trials is an active area of investigation, but the factors that determine clinical trial enrollment following a molecular prescreening ...