Browsing by Subject "computational biology"
Now showing items 1-9 of 9
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A Framework for Dissecting and Applying Bacterial Antibiotic Responses
(2017)An essential property of microbial communities is the ability to survive a disturbance. This is readily observed in bacteria, which have developed the ability to survive every antibiotic treatment at an alarming rate, considering ... -
Computational Molecular Engineering Nucleic Acid Binding Proteins and Enzymes
(2010)Interactions between nucleic acid substrates and the proteins and enzymes that bind and catalyze them are ubiquitous and essential for reading, writing, replicating, repairing, and regulating the genomic code by the proteomic ... -
Exploring the structurial diversity and engineering potential of thermophilic periplasmic binding proteins
(2007-05-02)The periplasmic binding protein (PBP) superfamily is found throughout the genosphere of both prokaryotic and eukaryotic organisms. PBPs function as receptors in bacterial solute transport and chemotaxis systems; however ... -
Genome-wide Analysis of Chromatin Structure across Diverse Human Cell Types
(2013)Chromatin structure plays an important role in gene regulation, especially in differentiating the diverse cell types in humans. In this dissertation, we analyze the nucleosome positioning and open chromatin profiles genome-wide ... -
Modeling Biological Systems from Heterogeneous Data
(2008-04-24)The past decades have seen rapid development of numerous high-throughput technologies to observe biomolecular phenomena. High-throughput biological data are inherently heterogeneous, providing information at the various ... -
Pattern Formation in Engineered Bacteria: from Understanding to Applications
(2017)Patterns are ubiquitous in living organisms. However, the mechanisms driving self-organized pattern formations are not well understood. Due to the complexity of natural systems, many confounding factors complicate quantitative ... -
Punctuated evolution and transitional hybrid network in an ancestral cell cycle of fungi.
(Elife, 2016-05-10)Although cell cycle control is an ancient, conserved, and essential process, some core animal and fungal cell cycle regulators share no more sequence identity than non-homologous proteins. Here, we show that evolution along ... -
Regulation of Global Transcription Dynamics During Cell Division and Root Development
(2009)The successful completion of many critical biological processes depends on the proper execution of complex spatial and temporal gene expression programs. With the advent of high-throughput microarray technology, it is now ... -
The Effect of Structural Microheterogeneity on the Initiation and Propagation of Ectopic Activity in Cardiac Tissue
(2010)Cardiac arrhythmias triggered by both reentrant and focal sources are closely correlated with regions of tissue characterized by significant structural heterogeneity. Experimental and modeling studies of electrical activity ...
