Browsing by Subject "copper"
Now showing items 1-12 of 12
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Characterization of Drosophila Ctr1a: New Roles for Ctr1 Proteins and Copper in Physiology and Cell Signaling Pathways
(2008-10-21)Copper is an essential trace element required by all aerobic organisms as a co-factor for enzymes involved in normal growth, development and physiology. Ctr1 proteins are members of a highly conserved family of copper importers ... -
Control of copper homeostasis by regulation of the high affinity copper transporter Ctr1
(2017)Copper is an essential element due to its unique ability to cycle between redox states under biological conditions. This property makes copper an ideal catalytic co-factor for enzymes that function in energy generation, ... -
Copper as an Antibacterial Agent and Disruptor of Protein Stability
(2020)The emergence of resistance to existing antibiotic drugs necessitates the development of new strategies to treat bacterial infections. Copper (Cu) has been used since ancient times to inhibit bacterial growth and has recently ... -
Copper-Catalyzed Amino Oxygenation of Alkenes and Dienes: A Novel Amino-Initiation Pathway Using O-Benzoylhydroxylamines
(2018)Nitrogen-containing compounds, specifically the 1,2-oxyamino moiety, are of vital importance to modern pharmaceuticals, natural products, and agrochemicals. 1,2-Difunctionalization of alkenes offers an efficient approach ... -
Development of a beta-Secretase Activated Prochelator and FRET Probe to Mediate Copper Toxicity in Alzheimer's Disease
(2012)Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects over 5 million people in the United States alone. This number is predicted to triple to by the year 2050 due to both increasing life expectancies ... -
Development of Fluorescent Iron and Copper Sensors Activated by Hydrogen Peroxide or Ultraviolet Light
(2011)Fluorescent sensors provide a powerful analytical tool for the intracellular detection of metal cations. In some cases, these fluorescent metal-chelating sensors have helped elucidate the function of metal cations within ... -
Evaluating the copper-binding properties of the antifungal peptide histatin 5
(2014)Histatins are a family of histidine-rich peptides that are found in saliva. This family of peptides has antifungal properties. In this family, histatin 5 is the most efficient antifungal peptide against Candida albicans. ... -
Insight into How the Coordination Environment of Cu Influences Chemical and Biological Activity of the Antifungal Peptide Histatin-5
(2019)The histidine-rich salivary peptides of the histatin family are known to bind copper (Cu) and other metal ions in vitro, but the details of these interactions are poorly understood and their implications on in vivo antifungal ... -
Low temperature amorphization and superconductivity in FeSe single crystals at high pressures
(2010)In this study, we report low temperature x-ray diffraction studies combined with electrical resistance measurements on single crystals of iron-based layered superconductor FeSe to a temperature of 10 K and a pressure of ... -
Synthesis of Protected Amines from Azadiene and Azaallyl Anion Building Blocks
(2018)Amines are ubiquitous in medicinal compounds and essential to human health. We have addressed the limitations of amine synthesis by significantly expanding the utility of 2-azaallyl anions and 2-azaallyl anion-like reagents ... -
Targeting Drug-Resistant Bacteria with Metal-Binding Compounds for Antibacterial Activity and Metallo-β-Lactamase Inhibition
(2020)New strategies are urgently needed to overcome the growing threat of antibacterial drug resistance. One mechanism of drug resistance commonly employed by bacterial pathogens is expression of β-lactamases, which confer resistance ... -
The Development of Enzyme-Activated Prochelators Designed to Target Cancer Cells Overexpressing γ-glutamyltransferase
(2017)Millions of people around the world eventually develop or currently suffer from some form of cancer. According to the American Cancer Society, 1.6 million new cases of cancer were predicted in the United States alone.One ...
