Browsing by Subject "cytokines"
Now showing items 1-8 of 8
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Cytokine biomarkers in tear film for primary open-angle glaucoma.
(Clin Ophthalmol, 2017)PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from ... -
Developmental Programming of Brain and Behavior: A Role for the Innate Immune System of the Placenta and Brain?
(2015)The field of "perinatal programming" has increasingly implicated an adverse early-life environment in the etiology of many chronic health problems and mental disorders. The following dissertation research is based on the ... -
Examining the Effect of the Context of Heat-Labile Enterotoxin Presentation on the Host Immune Response
(2011)Enterotoxigenic Escherichia coli (ETEC), the leading cause of traveler's diarrhea and childhood mortality due to diarrhea in the developing world, has been shown to secrete heat-labile enterotoxin (LT) in association with ... -
Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.
(Kidney Int, 2016-05)Activated Wnt signaling is critical in the pathogenesis of renal fibrosis, a final common pathway for most forms of chronic kidney disease. Therapeutic intervention by inhibition of individual Wnts or downstream Wnt/β-catenin ... -
Neuroimmune Signaling in the Hippocampus: Mechanisms of Risk and Resilience
(2014)The interactions between the brain and the immune system are extensive and each has a profound influence on the other. The hippocampus is a brain region that is strongly impacted by the immune system, especially considering ... -
NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats.
(Neurourology and urodynamics, 2018-03)Denervation of the bladder is a detrimental consequence of bladder outlet obstruction (BOO). We have previously shown that, during BOO, inflammation triggered by the NLRP3 inflammasome in the urothelia mediates physiological ... -
Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells.
(Molecular and cellular biology, 2018-11)While several protein serine/threonine kinases control cytokine production by T cells, the roles of serine/threonine phosphatases are largely unexplored. Here, we analyzed the involvement of protein phosphatase 1α (PP1α) ... -
The relationship between blood IL-12p40 level and melanoma progression.
(Int J Cancer, 2015-04-15)Cytokines such as Interleukin (IL)-12p70 ("IL-12") and IL-23 can influence tumor progression. We tested the hypothesis that blood levels of IL-12p40, the common subunit of both cytokines, are associated with melanoma progression. ...
