Browsing by Subject "drug delivery"
Now showing items 1-18 of 18
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Application of Repetitive Protein Polypeptides with an Upper Critical Solution Temperature at Various Length Scales
(2019)Phase separation of macromolecules is a critical phenomenon for the human condition. This phenomenon has also been exploited for biotechnological development to improve human morbidity and mortality. However, there is ... -
Assembly of Highly Asymmetric Genetically-Encoded Amphiphiles for Thermally Targeted Delivery of Therapeutics
(2013)Traditional small molecule chemotherapeutics show limited effectiveness in the clinic as their poor pharmacokinetics lead to rapid clearance from circulation and their exposure to off-target tissues results in dose-limiting ... -
Development of Delivery Strategies Facilitating Broad Application of Messenger RNA Tumor Vaccine
(2014)Genetic modification of dendritic cells with plasmid DNA is plagued with low transfection efficiencies because DNA taken up by non-dividing dendritic cells rarely reaches the nucleus. But this difficulty can be overcome ... -
Development of Depot Forming Elastin-Like Polypeptide-Curcumin Drug Conjugates for Sustained Drug Delivery to Treat Neuroinflammatory Pathologies
(2013)Neuroinflammation associated with lumbar radiculopathy and peripheral nerve injury is characterized by locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). Systemic administration ... -
Development of Genetically Encoded Zwitterionic Polypeptides for Drug Delivery
(2019)The clinical utility of many peptide, protein and small molecule drugs is limited by their short in-vivo ¬half-life. To address this limitation, we report a new class of biomaterials that have a long plasma circulation time. ... -
Development of Plasmonics-active Nanoconstructs for Targeting, Tracking, and Delivery in Single Cells
(2010)Although various proof-of-concept studies have demonstrated the eventual potential of a multifunctional SERS-active metallic nanostructures for biological applications such as single cell analysis/measurement and drug delivery, ... -
Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
(2010)Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumor. Relying on the EPR effect (Enhanced Permeability and Retention), a host ... -
Injectable Ablation Technique for Cancer Treatment Across Clinical Settings
(2023)Cancer treatment regimens often include surgery, radiation, and chemotherapy. Though the World Health Organization (WHO) Essential Medicines List includes many globally accessible chemotherapies, surgery and radiation are ... -
Intra-articular Clearance of Silk Microparticles and Macromolecules in Healthy and Arthritic Rat Knee Joints
(2015)Osteoarthritis (OA) is a degenerative disease of articular joints characterized by progressive deterioration of the cartilage lining, subchondral bone destruction and thickening of the joint capsule. These tissue changes ... -
Liposomal Drug Delivery Mediated by MR-guided High Intensity Focused Ultrasound: Drug Dose Painting and Influence of Local Tissue Transport Parameters
(2014)Use of chemotherapeutics in treatment of solid tumors suffers from insufficient and heterogeneous drug delivery, systemic toxicity and lack of knowledge of delivered drug concentration. The overall objectives of this work ... -
Microfluidics-Generated Biodegradable Polymeric Microparticles for Controlled Drug Delivery
(2014)While drug-loaded biodegradable polymer microparticles have found many therapeutic applications, bulk manufacturing methods produce heterogeneous populations of particles. A more highly controlled manufacturing method may ... -
Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery.
(Int J Nanomedicine, 2012)BACKGROUND: Modular nanotransporters (MNT) are recombinant multifunctional polypeptides created to exploit a cascade of cellular processes, initiated with membrane receptor recognition to deliver selective short-range and ... -
Near-Infrared Quantum Dots For Bioimaging And Targeting Applications
(2014)Luminescent semiconductor nanocrystals or quantum dots (QDs) offer attractive characteristics as a new class of fluorescent probes for molecular, cellular and in vivo imaging. While traditional cadmium-containing QDs have ... -
Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury.
(Advanced functional materials, 2019-01)Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy is vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion ... -
Stealth Polymer Conjugates of Biologics
(2021)Biologics are potent, highly specific, and well-tolerated and have become an important class of drugs. Despite their promise, most of them have a short half-life due to rapid renal elimination and in vivo degradation. Their ... -
The Immunoengineering Toolbox: A Set of Thermoresponsive Biopolymers for Sustained Delivery of Cancer Immunotherapies
(2022)Therapeutic cancer vaccines have the potential to revolutionize cancer treatment by providing systemic control of both local and metastatic malignancies. However, stimulating antitumor immune responses in patients with cancer ... -
Thermally Responsive Hydrogel-Nanoparticle Composite Materials for Therapeutic Delivery
(2014)Cancer is currently the second leading cause of death in the United States. Although many treatment options exist, some of the most common, including radiotherapy and chemotherapy, are restricted by dose-limiting toxicities. ... -
Transport Phenomena in Anti-HIV Microbicide Delivery Vehicles
(2008-04-21)There were 2.5 million people newly infected with HIV in 2007, clearly motivating the need for additional novel prevention methods. In response, topical vaginal antimicrobials, or microbicides, are being developed. These ...
