Browsing by Subject "electrophysiology"
Now showing items 1-9 of 9
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A modular simulation system for the bidomain equations
Cardiac arrhythmias and fibrillation are potentially life threatening diseases that can result from the improper conduction of electrical impulses in the heart. Experimental study of such cardiac abnormalities are dangerous ... -
Bridging Scales: How Microstructural Features Impact Macroscopic Cardiac Propagation
(2018)Cardiac arrhythmias such as atrial fibrillation and ventricular tachycardia are closely associated with microscopic fibrotic changes in cardiac structure that result in a heterogeneous myocardium. While the incidence of ... -
Electrophysiology of Gαz protein as a mediator for seizure susceptibility
(2016-05-06)Seizures are marked by a state of irregular, recurrent neuronal activity in the brain. Seizures are typical across a wide range of disorders including epilepsy, autism, and they are high comorbidity with anxiety disorders. In ... -
Engineering Prokaryotic Sodium Channels for Excitable Tissue Therapies
(2017)Voltage-gated sodium channels (VGSCs) enable generation and spread of action potentials in electrically excitable cells and tissues of all metazoans, from jellyfish to humans. The functional, pore-forming α-subunit of eukaryotic ... -
Functional Brain Networks Underlying Anticipation in Motivated Behavior
(2018)Anticipation is a state of expectancy for something that will happen, and it allows us to use past learning to prepare for and make predictions about the future. Studies have shown that anticipation influences behavioral ... -
Functional studies of the domains of Piezo1 ion channels
(2018)Mechanosensation, or the ability to sense mechanical forces, is critical for the survival of all organisms. For vertebrates, the ability to sense and respond to environmental stimuli, or somatosensation, is not well understood ... -
Quantifying High Dimensional Recordings of Neural Surface Potentials
(2018)Chronically reliable neural implants are needed to provide long lasting, high fidelity interfaces for clinical use and for basic science. Minimally invasive implants, such as micro-electrocorticographic arrays (µECoG), have ... -
Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
(eLife, 2019-05-09)Temperature-sensitive transient receptor potential vanilloid (thermoTRPV) channels are activated by ligands and heat, and are involved in various physiological processes. ThermoTRPV channels possess a large cytoplasmic ring ... -
The Roles of Focal Adhesion Assembly in Membrane Localization of Ion Channels and Action Potential Shape
(2019)Action potential firing in various excitable cells (cardiomyocytes, neurons, smooth and skeletal muscle cells) is enabled by the presence of inwardly rectifying potassium channels, such as Kir2.1, which set the resting membrane ...
