Browsing by Subject "epigenetics"
Now showing items 1-20 of 21
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A Neuronal Activity-Dependent Dual Function Chromatin-Modifying Complex Regulates Arc Expression(1,2,3).
(eNeuro, 2015-01)Chromatin modification is an important epigenetic mechanism underlying neuroplasticity. Histone methylation and acetylation have both been shown to modulate gene expression, but the machinery responsible for mediating these ... -
Behavior Genetics and Post Genomics
(Behavioral and Brain Sciences, 2012-12)The science of genetics is undergoing a paradigm shift. Recent discoveries, including the activity of retrotransposons, the extent of copy number variations, somatic and chromosomal mosaicism, and the nature of the epigenome ... -
Cellular Reprogramming in Response to Viral Infection and Oncogenic Transformation
(2021)In this dissertation, I reported several cellular reprogramming mechanisms in response to different factors, such as viral infection and oncogenic transformation, by utilizing molecular biology and high-throughput sequencing ... -
Developmental plasticity research in evolution and human health: Response to commentaries.
(Evolution, medicine, and public health, 2017-01) -
Genes, Environment, and Epigenetics in Neural Tube Defects
(2014)Neural tube defects (NTDs) are a common class of human birth defects with a complex, multifactorial etiology. Although many contributing factors have been identified, an estimated 60% of human population risk remains ... -
Glutaminase Modulates T Cell Metabolism and Function in Inflammation and Cancer
(2018)During the immune response, helper T cells must proliferate and upregulate key metabolic programs including glucose and glutamine uptake. Metabolic reprogramming is imperative for appropriate T cell responses, as inhibition ... -
Individual Differences in Neural Reward and Threat Processing: Identifying Pathways of Risk and Resilience for Psychopathology
(2014)The goal of this dissertation is two-fold: 1) to identify novel biological pathways implicating individual differences in reward and threat processing in the emergence of risk and resilience for psychopathology, 2) to identify ... -
Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans.
(Genetics & epigenetics, 2014-01)In infants exposed to maternal stress in utero, phenotypic plasticity through epigenetic events may mechanistically explain increased risk of preterm birth (PTB), which confers increased risk for neurodevelopmental disorders, ... -
MicroRNA and Epigenetic Controls of CD4+ T cells' Activation, Differentiation and Maintenance
(2014)As a major component of the adaptive immune system, CD4+ T cells play a vital role in host defense and immune tolerance. The potency and accuracy of CD4+ T cell-mediated protection lie in their ability to differentiate into ... -
Non-genetic Alterations in Colorectal Cancer Liver Metastasis and Patient-derived Models
(2022)Colorectal cancer (CRC) is the third most diagnosed type of cancer, and the 5-year survival rate drops significantly once the patient develops liver metastases. Notably, over the past decade, multiple patient-derived models ... -
Nuclear Arc Interacts with the Histone Acetyltransferase Tip60 to Modify H4K12 Acetylation(1,2,3).
(eNeuro, 2014-11)Arc is an immediate-early gene whose genetic ablation selectively abrogates long-term memory, indicating a critical role in memory consolidation. Although Arc protein is found at synapses, it also localizes to the neuronal ... -
Persistent Life History Effects of Extended Starvation
(2013)Starvation during early human development produces epigenetic effects that could be adaptive if famine persists. We modeled the response to early starvation exposure in C. elegans using `L1 arrest,' a reversible developmental ... -
Pre-birth acquisition of personhood: Incremental accrual of attributes as the framework for individualization by serial and concurrently acting developmental factors.
(Frontiers in reproductive health, 2023-01)Discrete events and processes influence development of individual humans. Attribution of personhood to any individual human being cannot be disconnected from the underlying biological events and processes of early human ... -
Refraining from use diminishes cannabis-associated epigenetic changes in human sperm.
(Environmental epigenetics, 2021-01)Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period ... -
Regulation of Adaptive Immune Cells by Sirtuins
(Frontiers in Endocrinology, 2019-07-11) -
States of Allelic Imbalance on the X Chromosomes in Human Females
(2011)Allelic imbalance, in which two alleles at a given locus exhibit differences in gene expression, chromatin composition and/or protein binding, is a widespread phenomenon in the human and other complex genomes. Most examples ... -
The Balance of Parental Effects and Within Generation Plasticity: The Role of Parent and Offspring DNA Methylation on Response to Cues of Neighbor Presence
(2021)While phenotypic plasticity has been widely documented, the relative contribution of parent versus offspring environment to determining progeny phenotypes and the persistence of parental effects throughout progeny development ... -
The Elucidation of the Mechanisms of CD8+ T Cell-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication
(2010)Herein we detail the progress made at understanding the overall process of CD8<super>+</super> T-lymphocyte noncytolytic antiviral response (CNAR). This response is comprised of 3 key components, the virus, the effector ... -
The Epigenetic and Neurodevelopmental Consequences of Maternal Tobacco Smoke Exposure
(2019)Maternal smoking is a deleterious and preventable risk to fetal health. Maternal tobacco smoke (TS) exposure in humans has been linked to impaired fetal growth, preterm birth, sudden infant death syndrome, and neurobehavioral ... -
The Genetic and Epigenetic Landscape of Oxytocin Signaling in the Social Brain of Humans and Mice
(2021)Human beings are inherently social. As we grow, the interactions we have with those around us become the foundation of the relationships with our families, friends, educators, and caretakers. Aberrant social behavioral traits ...
