Browsing by Subject "expression"
Now showing items 1-9 of 9
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Bifurcation Analysis of Gene Regulatory Circuits Subject to Copy Number Variation
(2010)Gene regulatory networks are comprised of many small gene circuits. Understanding expression dynamics of gene circuits for broad ranges of parameter space may provide insight into the behavior of larger regulatory networks ... -
Genome-wide Cross-species Analysis Linking Open Chromatin, Differential Expression and Positive Selection
(2012)Deciphering the molecular mechanisms driving the phenotypic differences between humans and primates remains a daunting challenge. Mutations found in protein coding DNA alone has not been able to explain these phenotypic ... -
Interchangeable Domains in the Kdo Transferases of Escherichia coli and Haemophilus influenzae
(2010)Kdo(2)-lipid A, a conserved substructure of lipopolysaccharide, plays critical roles in Gram-negative bacterial survival and interaction with host organisms. Inhibition of Kdo biosynthesis in Escherichia coli results in ... -
Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans
(2010)To define the mechanisms involved in the molecular response to the carcinogenic metal cadmium, two novel metal-inducible genes from C. elegans were characterized: numr-1 and numr-2 (nuclear localized metal responsive). numr-1 ... -
Nutritional Control of L1 Arrest and Recovery in Caenorhabditis elegans by Insulin-like Peptides and Signaling
(2014)Animals must coordinate development with fluctuating nutrient availability. Nutrient availability governs post-embryonic development in Caenorhabditis elegans: larvae that hatch in the absence of food do not initiate ... -
Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line
(2010)Background: Multicellular organisms are characterized by a remarkable diversity of morphologically distinct and functionally specialized cell types. Transgenic techniques for the manipulation of gene expression in specific ... -
Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background
(2011)Human germ cell tumors show a strong sensitivity to genetic background similar to Dnd1(Ter/Ter) mutant mice, where testicular teratomas arise only on the 129/SvJ genetic background. The introduction of the Bax mutation onto ... -
States of Allelic Imbalance on the X Chromosomes in Human Females
(2011)Allelic imbalance, in which two alleles at a given locus exhibit differences in gene expression, chromatin composition and/or protein binding, is a widespread phenomenon in the human and other complex genomes. Most examples ... -
Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning
(2010)Integration of muscle, connective tissue and skeletal patterning during development is essential for proper functioning of the musculoskeletal system. How this integration is achieved is poorly understood. There is ample ...
