Browsing by Subject "gene expression"
Now showing items 1-20 of 25
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A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
(Open Forum Infect Dis, 2016-01)Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores ... -
An age-independent gene signature for monitoring acute rejection in kidney transplantation.
(Theranostics, 2020-01)Acute rejection (AR) remains a significant problem that negatively impacts long-term renal allograft survival. Numerous therapies are used to prevent AR that differ by center and recipient age. This variability confounds ... -
Bacterial Responses to Silver Nanoparticle Treatment: Community Structure, Resistance, and Function.
(2016)The antimicrobial properties of silver have been taken advantage of by societies for thousands of years. Its use has come back in favor in the form of silver nanoparticles, which are highly efficacious antimicrobial agents. ... -
Bayesian Models for Relating Gene Expression and Morphological Shape Variation in Sea Urchin Larvae
(2012)A general goal of biology is to understand how two or more sets of traits in an organism are related - for example, disease state and genetics, physiology and behavior, or phenotypic variation and gene function. Many of ... -
Comparing the Diagnostic Accuracy of Clinician Judgment to a Novel Host Response Diagnostic for Acute Respiratory Illness.
(Open forum infectious diseases, 2021-12)<h4>Background</h4>Difficulty discriminating bacterial from viral infections drives antibacterial misuse. Host gene expression tests discriminate bacterial and viral etiologies, but their clinical utility has not ... -
Computational Methods for Investigating Dendritic Cell Biology
(2011)The immune system is constantly faced with the daunting task of protecting the host from a large number of ever-evolving pathogens. In vertebrates, the immune response results from the interplay of two cellular systems: ... -
Detecting Changes in Alternative mRNA Processing From Microarray Expression Data
(2010)Alternative mRNA processing can result in the generation of multiple, qualitatively different RNA transcripts from the same gene and is a powerful engine of complexity in higher organisms. Recent deep sequencing studies ... -
Functional and Evolutionary Genetics of a Wild Baboon Population
(2010)Although evolution results from differential reproduction and survival at the level of the individual, most research in evolutionary genetics is concerned with comparisons made at the level of divergent populations or species. ... -
Functional Interactions and Evolution of cAMP-PKA Signaling in Saccharomyces
(2013)In an attempt to gain more insight on functional evolution of cAMP-PKA pathway I have taken a comparative approach and examined functional interactions of cAMP-PKA signaling in well-studied yeast developmental programs and ... -
Gene level analysis of Endothelial Progenitor Cells in Co-culture
(2011)hCB-ECs show varying morphology under co-culture conditions. They are known to form networks when co-cultured on matrices like Matrigel, collagen gels and SMCs. Optimizing the co-culture model for the formation of networks ... -
Genetic and Environmental Constraints on Developmental Systems: Towards Predicting Genetic Responses to Climate Change in Sea Urchins
(2012)Many factors, including gene networks, developmental processes, and the environment mediate the link between the activity of genes and complex phenotypes in higher organisms. While genetic variants are the raw material for ... -
Genomic Signatures of Disease and Environmental Exposure in the Peripheral Blood
(2011)My thesis research has centered on the concept of the peripheral blood cell (PBC) as an indicator of disease and environmental exposure. The PBC is not only easily accessible and constantly replenished, but it provides a ... -
Immunologic Targeting and Biologic Underpinnings of Human Cytomegalovirus in Glioblastoma
(2015)Glioblastoma (GBM) is a grade IV astrocytoma in which the median overall survival is approximately 15 months at time of diagnosis. Even with the current multi- modal therapeutic approach of surgery, chemotherapy with the ... -
Investigating the Genetic, Evolutionary, and Functional Mechanisms of Adaptations to Copper Mine Tailings in Mimulus guttatus
(2017)The evolution of copper tolerance in the common yellow monkeyflower, Mimulus guttatus, is a classic example of rapid adaptation in plants; however, little is yet known about the genetic, functional, and evolutionary mechanisms ... -
Invited Commentary: Integrating Genomics and Social Epidemiology-Analysis of Late-Life Low Socioeconomic Status and the Conserved Transcriptional Response to Adversity.
(Am J Epidemiol, 2017-09-01)Socially disadvantaged children face increased morbidity and mortality as they age. Understanding mechanisms through which social disadvantage becomes biologically embedded and devising measurements that can track this embedding ... -
Methods for Systematic Exploratory Analysis of Gene Expression Data with Applications to Cancer Genomics
(2017)Advances in technologies for gene expression profiling have resulted in an unprecedented abundance of gene expression data. However, computational methods available for the exploratory analysis of such data are limited in ... -
Morphological and genomic shifts in mole-rat 'queens' increase fecundity but reduce skeletal integrity.
(eLife, 2021-04-12)In some mammals and many social insects, highly cooperative societies are characterized by reproductive division of labor, in which breeders and nonbreeders become behaviorally and morphologically distinct. While differences ... -
On Science and Communication: Exploring the Azolla-Nostoc Symbiosis and Connecting Science With Society
(2019)Science has an inspiring capacity to change the world around us as it informs of the details governing life. From feats of engineering to medical breakthroughs, it has rapidly changed the way we live. Though it is woven ... -
Posttranscriptional Gene Regulation: From Global Models to Functional Mechanisms
(2014)Precise regulation of the complex process of gene expression is essential for all aspects of life, and a large degree of this precision is mediated at the posttranscriptional level. The global and individual mechanisms ... -
Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.
(Open forum infectious diseases, 2020-06)Background:Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately ...
