Browsing by Subject "human"
Now showing items 1-16 of 16
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A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division.
(Elife, 2016-04-14)The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here ... -
A phylogenetic transform enhances analysis of compositional microbiota data.
(Elife, 2017-02-15)Surveys of microbial communities (microbiota), typically measured as relative abundance of species, have illustrated the importance of these communities in human health and disease. Yet, statistical artifacts commonly plague ... -
Ambiguously Human: Questioning the Dichotomy between Human and Object
(2016-04-25)*Designated as an exemplary master's project for 2015-16*How can bringing together different investigations of defining “human” as opposed to “object” generate new ideas and questions? I looked at a small group of publicly ... -
Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut.
(eLife, 2018-06-19)How host and microbial factors combine to structure gut microbial communities remains incompletely understood. Redox potential is an important environmental feature affected by both host and microbial actions. We assessed ... -
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
(Elife, 2015-01-09)Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering ... -
Cannabinoid exposure and altered DNA methylation in rat and human sperm.
(Epigenetics, 2018-01)Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and ... -
Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.
(Elife, 2017-04-20)Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV expresses viral oncogenes that promote cell growth and inhibit the apoptotic response to uncontrolled proliferation. The EBV oncoprotein ... -
Genome-wide Cross-species Analysis Linking Open Chromatin, Differential Expression and Positive Selection
(2012)Deciphering the molecular mechanisms driving the phenotypic differences between humans and primates remains a daunting challenge. Mutations found in protein coding DNA alone has not been able to explain these phenotypic ... -
I see what you are saying.
(Elife, 2016-06-09)The motor cortex in the brain tracks lip movements to help with speech perception. -
Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.
(J Orthop Res, 2013-10)The extracellular matrix (ECM) of the human intervertebral disc is rich in molecules that interact with cells through integrin-mediated attachments. Porcine nucleus pulposus (NP) cells have been shown to interact with laminin ... -
Numerical Modeling of Coastline Evolution in an Era of Global Change
(2008-04-16)Scientists expect temperatures on Earth to get substantially warmer over the course of the 21st century, causing storm systems to intensify and sea-level rise to accelerate--these changes will likely have dramatic impacts ... -
One Health training, research, and outreach in North America.
(Infect Ecol Epidemiol, 2016)BACKGROUND: The One Health (OH) concept, formerly referred to as 'One Medicine' in the later part of the 20th century, has gained exceptional popularity in the early 21st century, and numerous academic and non-academic ... -
Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm.
(eLife, 2020-05-05)Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints ... -
Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
(eLife, 2019-05-09)Temperature-sensitive transient receptor potential vanilloid (thermoTRPV) channels are activated by ligands and heat, and are involved in various physiological processes. ThermoTRPV channels possess a large cytoplasmic ring ... -
RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin.
(Elife, 2017-08-01)Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. ... -
Role of MicroRNAs in Human Skeletal Muscle Tissue Engineering In Vitro
(2014)The development of a functional tissue-engineered human skeletal muscle model in vitro would provide an excellent platform on which to study the process of myogenesis, various musculoskeletal disease states, and drugs and ...
