Browsing by Subject "hyperpolarization"
Now showing items 1-5 of 5
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(15)N Hyperpolarization of Imidazole-(15)N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH.
(ACS Sens, 2016-06-24)(15)N nuclear spins of imidazole-(15)N2 were hyperpolarized using NMR signal amplification by reversible exchange in shield enables alignment transfer to heteronuclei (SABRE-SHEATH). A (15)N NMR signal enhancement of ∼2000-fold ... -
Development of Novel Physical Methods to Enhance Contrast and Sensitivity in Magnetic Resonance Imaging
(2010)The purpose of this thesis is to report technological developments in contrast mechanisms for MRI. The search for new forms of contrast is on-going, with the hope that new contrast mechanisms and new contrast agents will ... -
Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal (15)N2-diazirine molecular tags.
(Sci Adv, 2016-03)Conventional magnetic resonance (MR) faces serious sensitivity limitations which can be overcome by hyperpolarization methods, but the most common method (dynamic nuclear polarization) is complex and expensive, and applications ... -
Making Nuclear Magnetic Hyperpolarization Practical through Storage in Disconnected Eigenstates
(2015)There are two fundamental limitations in magnetic resonance: the poor signal amplitude and the short duration before the system return to equilibrium. Hyperpolarization methods solve the problem of signal amplitude, however, ... -
The Synthesis of Novel N-Heterocyclic Scaffolds and Diazirine-Based Molecular Tags
(2016)N-Heterocycles are ubiquitous in biologically active natural products and pharmaceuticals. Yet, new syntheses and modifications of N-heterocycles are continually of interest for the purposes of expanding chemical space, ...
