Browsing by Subject "hypoxia"
Now showing items 1-15 of 15
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3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.
(Matrix biology : journal of the International Society for Matrix Biology, 2022-06-04)Pulmonary hypertension (PH) comprises a diverse group of disorders that share a common pathway of pulmonary vascular remodeling leading to right ventricular failure. Development of anti-remodeling strategies is an emerging ... -
A Paradoxical Role for PTEN in the Cellular Response to Hypoxia
(2010)Regulation of cell growth is controlled by a variety of factors, including a number of oncogenes and tumor suppressors. PTEN is an inositol phosphatase that regulates cell growth by hydrolyzing the phospholipid products ... -
Bioenergetic and Fitness Costs of PAH Adapted Fundulus heteroclitus to Early Life PAH and Hypoxia Exposures
(2019-04-26)Growing evidence suggests that acute polycyclic aromatic hydrocarbon (PAH) exposures have toxic mitochondrial effects and may inhibit aerobic respiration. However, the effect of subteratogenic exposures during development ... -
Drug Delivery and Anti-Vascular Effects of Temperature Sensitive Liposomal Doxorubicin
(2010)Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumor. Relying on the EPR effect (Enhanced Permeability and Retention), a host ... -
Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
(2015)In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. Additionally, cancer cells exposed to these stresses are ... -
Interactions Between Environmental Factors and Polycyclic Aromatic Hydrocarbons (PAHs) in Developing Fish: Molecular and Developmental Implications
(2010)Aquatic systems are impacted by a wide variety of natural and anthropogenic stressors. Laboratory studies often focus on impacts of a single stressor, ignoring how these stressors may interact. This dissertation focuses ... -
Mechanisms Regulating Pulmonary Sensitivity to Radiation
(2012)At the present time, here is no approved medical countermeasure (MCM) for mitigating or treating pneumonitis/fibrosis following acute radiation exposure. Since it is neither ethical nor feasible to evaluate potential MCMs ... -
Metabolic Exogenous Contrast Agents for use in Breast Cancer Detection and Therapy Monitoring
(2010)Functional imaging gives clinicians the ability to monitor breast cancer progression and response to therapy. Modern techniques such as Positron Emission Tomography (PET) has allowed for clinicians to visualize the metabolic ... -
Metabolic Targeting of Cancer Cells: Two Molecular Mechanisms Involving Glucose Metabolism
(2009)Selective therapeutic targeting of tumors requires identification of differences between the homeostatic requirements of cancer and host cells. One such difference is the manner in which cancer cells acquire energy. Cancer ... -
Pannexin 1 Channels Control the Hemodynamic Response to Hypoxia by Regulating O2-Sensitive Extracellular ATP in Blood.
(American journal of physiology. Heart and circulatory physiology, 2021-01-15)Pannexin1 (Panx1) channels export ATP and may contribute to increased concentration of the vasodilator ATP in plasma during hypoxia in vivo. We hypothesized that Panx1 channels and associated ATP export contributes to hypoxic ... -
Seafood prices reveal impacts of a major ecological disturbance.
(Proc Natl Acad Sci U S A, 2017-02-14)Coastal hypoxia (dissolved oxygen ≤ 2 mg/L) is a growing problem worldwide that threatens marine ecosystem services, but little is known about economic effects on fisheries. Here, we provide evidence that hypoxia causes ... -
Synthetic Studies toward Analogues of Manassantin A
(2018)In response to oxygen deprivation, tumor cells express a transcription factor, hypoxia inducible factor 1 (HIF-1). HIF-1 regulates the expression of genes involved in erythropoiesis, angiogenesis, and other adaptive responses ... -
The Dewey monitor: Pulse oximetry can independently detect hypoxia in a rebreather diver.
(Undersea Hyperb Med, 2017-11)Rebreather diving has one of the highest fatality rates per man hour of any diving activity in the world. The leading cause of death is hypoxia, typically from equipment or procedural failures. Hypoxia causes very few symptoms ... -
Transcriptome and Functional Analysis of Carotid Body Glomus Cells
(2016)The carotid body (CB) is a major arterial chemoreceptor containing glomus cells that are activated by changes in arterial blood contents including oxygen. Despite significant advancement in the characterization of their ... -
Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.
(Hypoxia (Auckland, N.Z.), 2017-01)The "Hypoxia Nantes 2016" organized its second conference dedicated to the field of hypoxia research. This conference focused on "the role of hypoxia under physiological conditions as well as in cancer" and took place in ...
