Browsing by Subject "immunosuppression/immune modulation"

Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization.

Yu, Shuangjin; Dangi, Anil; Burnette, Melanie; Abecassis, Michael M; Thorp, Edward B; Luo, Xunrong (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020-07-13)

We have previously shown that acute cytomegalovirus (CMV) infection disrupts the induction of transplantation tolerance. However, what impact acute CMV infection would have on the maintenance of established tolerance and ...

Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.

Kwun, J; Page, E; Hong, JJ; Gibby, A; Yoon, J; Farris, AB; Villinger, F; ... (8 authors) (Am J Transplant, 2015-03)

Depletional strategies directed toward achieving tolerance induction in organ transplantation have been associated with an increased incidence and risk of antibody-mediated rejection (AMR) and graft injury. Our clinical ...

Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.

Oh, B; Yoon, J; Farris, A; Kirk, A; Knechtle, S; Kwun, J (Am J Transplant, 2016-09)

Previously, we demonstrated that alemtuzumab induction with rapamycin as sole maintenance therapy is associated with an increased incidence of humoral rejection in human kidney transplant patients. To investigate the role ...