Browsing by Subject "immunosuppression/immune modulation"

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Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model.

Farris, AB; Gibby, Adriana C; Hong, JJ; Knechtle, Stuart J; Kwun, J; Page, EK; Villinger, F; ... (8 authors) (Am J Transplant, 2015-03)

Depletional strategies directed toward achieving tolerance induction in organ transplantation have been associated with an increased incidence and risk of antibody-mediated rejection (AMR) and graft injury. Our clinical ...
Rapamycin Interferes With Postdepletion Regulatory T Cell Homeostasis and Enhances DSA Formation Corrected by CTLA4-Ig.

Farris, A; Kirk, Allan D; Knechtle, Stuart J; Kwun, J; Oh, B; Yoon, J (Am J Transplant, 2016-09)

Previously, we demonstrated that alemtuzumab induction with rapamycin as sole maintenance therapy is associated with an increased incidence of humoral rejection in human kidney transplant patients. To investigate the role ...