Browsing by Subject "infectious disease"
Now showing items 1-9 of 9
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A Decade On: Systematic Review of ClinicalTrials.gov Infectious Disease Trials, 2007-2017.
(Open forum infectious diseases, 2019-06)Background:Registration of interventional trials of Food and Drug Administration-regulated drug and biological products and devices became a legal requirement in 2007; the vast majority of these trials are registered in ... -
A phylogenetic transform enhances analysis of compositional microbiota data.
(Elife, 2017-02-15)Surveys of microbial communities (microbiota), typically measured as relative abundance of species, have illustrated the importance of these communities in human health and disease. Yet, statistical artifacts commonly plague ... -
Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut.
(eLife, 2018-06-19)How host and microbial factors combine to structure gut microbial communities remains incompletely understood. Redox potential is an important environmental feature affected by both host and microbial actions. We assessed ... -
Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.
(Elife, 2017-04-20)Latent Epstein-Barr virus (EBV) infection is causally linked to several human cancers. EBV expresses viral oncogenes that promote cell growth and inhibit the apoptotic response to uncontrolled proliferation. The EBV oncoprotein ... -
Haplotype Association Mapping Identifies a Candidate Gene Region in Mice Infected With Staphylococcus aureus.
(G3 (Bethesda), 2012-06)Exposure to Staphylococcus aureus has a variety of outcomes, from asymptomatic colonization to fatal infection. Strong evidence suggests that host genetics play an important role in susceptibility, but the specific host ... -
Hemorrhagic Herpes Simplex Virus Type 1 Nephritis: An Unusual Cause of Acute Allograft Dysfunction.
(Am J Transplant, 2017-01)Interstitial nephritis due to viruses is well-described after solid organ transplantation. Viruses implicated include cytomegalovirus; BK polyomavirus; Epstein-Barr virus; and, less commonly, adenovirus. We describe a rare ... -
Media Framing of the Ebola Crisis
(2016-01-24)This study examines the role of international media framing in coverage of Ebola. A quantitative content analysis compared framing techniques in Ebola coverage across BBC Monitoring, The New York Times, The Daily Telegraph ... -
Role of LAT in the Cytotoxicity and Memory Response of CD8 T Cells Following Microbial Infection
(2013)Linker for activation of T cells (LAT) is a transmembrane adaptor protein that is crucial in linking TCR engagement to downstream signaling events, such as calcium flux and Ras-MAPK pathway. Following TCR engagement, LAT ... -
Urban water, sanitation, and hygiene access and the presence of Escherichia coli in the urinary tracts of women in Ahmedabad, India
(2018)Introduction: Municipalities often struggle to build and maintain basic infrastructure for informal slums in urban cities for its most vulnerable populations. One impact of inadequate water and sanitation access is the creation ...
