Browsing by Subject "interferons"

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Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.

Katsura, Hiroaki; Sontake, Vishwaraj; Tata, Aleksandra; Kobayashi, Yoshihiko; Edwards, Caitlin E; Heaton, Brook E; Konkimalla, Arvind; ... (16 authors) (Cell stem cell, 2020-10-21)

Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an understanding of coronavirus disease 2019 (COVID-19) ...
Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.

Finethy, Ryan; Luoma, Sarah; Orench-Rivera, Nichole; Feeley, Eric M; Haldar, Arun K; Yamamoto, Masahiro; Kanneganti, Thirumala-Devi; ... (9 authors) (MBio, 2017-10-03)

The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of infected host cells and thereby prompts an inflammatory immune ...