Browsing by Subject "intervertebral disc"
Now showing items 1-9 of 9
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Cadherin-Mediated Cell-Cell Interactions Regulates Phenotype And Morphology of Nucleus Pulposus Cells Of The Intervertebral Disc
(2015)Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with numerous cell-cell interactions. With maturation and aging, NP cells lose their ability to form ... -
Changes in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy.
(Open Orthop J, 2012)Intervertebral disc herniation may contribute to inflammatory processes that associate with radicular pain and motor deficits. Molecular changes at the affected dorsal root ganglion (DRG), spinal cord, and even midbrain, ... -
Direct Differentiation of Mouse Induced Pluripotent Stem Cells into Nucleus Pulposus-Like Cells
(2012)The intervertebral discs (IVD) contribute to structural stability of the spinal column, attenuate the impact of compressive loads, and enable a wide spectrum of motions. As a consequence of aging, the majority of the adult ... -
Integrin-mediated interactions with extracellular matrix proteins for nucleus pulposus cells of the human intervertebral disc.
(J Orthop Res, 2013-10)The extracellular matrix (ECM) of the human intervertebral disc is rich in molecules that interact with cells through integrin-mediated attachments. Porcine nucleus pulposus (NP) cells have been shown to interact with laminin ... -
Laminin-Functionalized Polyethylene Glycol Hydrogels for Nucleus Pulposus Regeneration
(2013)Intervertebral disc (IVD) disorders and age-related degeneration are believed to contribute to low back pain. There is significant interest in cell-based strategies for regenerating the nucleus pulposus (NP) region of the ... -
Patterning Mechanisms Underlying Notochord and Spine Segmentation in Zebrafish
(2021)The defining characteristic of the subphylum Vertebrata is the vertebral column, which is comprised of alternating vertebral bodies and intervertebral discs. In spite of being a highly conserved structure, the morphogenetic ... -
Response of Midbrain Pain Receptors in a Rodent Model of Radiculopathy
(2012)<bold>Introduction:</bold> Intervertebral disc herniation may contribute to nerve root compression or inflammatory processes that are associated with radicular pain and motor deficits. Molecular changes at the affected dorsal ... -
The Effects of Extracellular Matrix Mechanics and Composition on the Behaviors of Nucleus Pulposus Cells from the Intervertebral Disc
(2009)Intervertebral disc (IVD) disorders are a major contributor to disability and health costs. Disc disorders and resulting pain may be preceded by changes which first occur in the nucleus pulposus (NP) region of the IVD, ... -
Vacuole Formation Guides the Regenerative Path of the Zebrafish Notochord
(2021)The notochord is a defining feature of our phylum Chordata and has critical roles in human development that are highly conserved in vertebrates. The notochord functions as a hydrostatic scaffold to provide structural rigidity ...
