Browsing by Subject "lactic acidosis"
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Cellular Responses to Lactic Acidosis in Human Cancers
(2010)The physiology of the tumor microenvironment is characterized by lower oxygen (hypoxia), higher lactate, extracellular acidosis and glucose starvation. We examined the global, transcriptional cellular responses to each of ... -
Genetic Determinants of Cancer Cell Survival in Tumor Microenvironment Stresses
(2015)In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. Additionally, cancer cells exposed to these stresses are ...
