Browsing by Subject "lipopolysaccharide"
Now showing items 1-9 of 9
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Degradation of Components of the Lpt Transenvelope Machinery Reveals LPS-Dependent Lpt Complex Stability in Escherichia coli.
(Frontiers in molecular biosciences, 2021-01)Lipopolysaccharide (LPS) is a peculiar component of the outer membrane (OM) of many Gram-negative bacteria that renders these bacteria highly impermeable to many toxic molecules, including antibiotics. LPS is assembled at ... -
Effect of LPS remodeling and LPS-binding proteins on outer membrane vesicle production and composition
(2017)Environmental transitions cause bacteria to simultaneously alter lipopolysaccharide (LPS) structure, release LPS-binding proteins, and increase outer membrane vesicle (OMV) production. However, any relationship between these ... -
Heat-labile enterotoxin: beyond G(m1) binding.
(Toxins (Basel), 2010-06)Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally ... -
Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM).
(American journal of obstetrics and gynecology, 2018-07)Preterm premature rupture of membranes is a leading contributor to maternal and neonatal morbidity and death. Epidemiologic and experimental studies have demonstrated that thrombin causes fetal membrane weakening and subsequently ... -
Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.
(MBio, 2017-10-03)The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of infected host cells and thereby prompts an inflammatory immune ... -
Interchangeable Domains in the Kdo Transferases of Escherichia coli and Haemophilus influenzae
(2010)Kdo(2)-lipid A, a conserved substructure of lipopolysaccharide, plays critical roles in Gram-negative bacterial survival and interaction with host organisms. Inhibition of Kdo biosynthesis in Escherichia coli results in ... -
Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats.
(Front Aging Neurosci, 2016)Systemic inflammation, for example as a result of infection, often contributes to long-term complications. Neuroinflammation and cognitive decline are key hallmarks of several neurological conditions, including advance age. ... -
Racial differences in the association of CD14 polymorphisms with serum total IgE levels and allergen skin test reactivity.
(Journal of asthma and allergy, 2013-01)BACKGROUND: The CD14 C-159T single nucleotide polymorphism (SNP) has been investigated widely as a candidate genetic locus in patients with allergic disease. There are conflicting results for the association of the CD14 ... -
Secretion and Lipopolysaccharide Binding of Heat-Labile Enterotoxin
(2010)Enterotoxigenic <italic>Escherichia coli</italic> (ETEC) is a leading cause of morbidity and mortality worldwide. The causative agent of traveler's diarrhea, ETEC is often associated with cholera-like disease, especially ...
