Browsing by Subject "mass spectrometry"
Now showing items 1-9 of 9
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A Study of Field Emission Based Microfabricated Devices
(2008-04-25)The primary goals of this study were to demonstrate and fully characterize a microscale ionization source (i.e. micro-ion source) and to determine the validity of impact ionization theory for microscale devices and pressures ... -
Coded Aperture Magnetic Sector Mass Spectrometry
(2015)Mass spectrometry is widely considered to be the gold standard of elemental analysis techniques due to its ability to resolve atomic and molecular and biological species. Expanding the application space of mass spectrometry ... -
Detection of Alternative Splice Variants at the Proteome Level in Aspergillus flavus
(2010)Identification of proteins from proteolytic peptides or intact proteins plays an essential role in proteomics. Researchers use search engines to match the acquired peptide sequences to the target proteins. However, search ... -
Development and Application of a Mass Spectrometry-Based Assay for the High Throughput Analysis of Protein-Ligand Binding
(2009)Many of the biological roles of proteins are modulated through protein-ligand interactions, making proteins important targets for drug therapies and diagnostic imaging probes. The discovery of novel ligands for a protein ... -
Development and Application of Covalent-Labeling Strategies for the Large-Scale Thermodynamic Analysis of Protein Folding and Ligand Binding
(2016)Thermodynamic stability measurements on proteins and protein-ligand complexes can offer insights not only into the fundamental properties of protein folding reactions and protein functions, but also into the development ... -
Evaluation of Energetics-based Techniques for Proteome-Wide Studies of Protein-Ligand Binding Interactions
(2015)Detection and quantification of protein-ligand binding interactions is extremely important for understanding interactions that occur in biological systems. Since traditional techniques for characterizing these types of ... -
Large-Scale Analysis of Protein Folding and Stability Changes Associated with Breast Cancer
(2018)Proteomic methods for disease state characterization and biomarker discovery have traditionally utilized quantitative mass spectrometry methods to identify proteins with altered expression levels in disease states. Unfortunately, ... -
Large-Scale Analysis of Protein-Gas and Protein-Metal Interactions using Mass Spectrometry-Based Proteomic Methods
(2022)Over the past two decades, a toolbox of mass spectrometry-based proteomic methods has been developed that enables the conformational properties of proteins and protein-ligand complexes to be probed in complex biological ... -
Proteomic Methods and Applications for Protein Folding Stability Measurements
(2019)In the last 10 years, several mass spectrometry-based proteomic techniques have been developed for the large-scale characterization of protein conformations, thermodynamic stabilities, and protein−ligand interactions. The ...
