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Browsing by Subject "medulloblastoma"
Now showing items 1-5 of 5
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Developmentally Regulated Antigens for Immunologic Targeting of Molecular Subtypes of Medulloblastoma
(2015)Medulloblastoma (MB) remains incurable in one third of patients despite aggressive multi-modality standard therapies. The heterogeneity of MB molecular subtypes as well as the failure of standard therapies to treat metastatic ... -
Investigating the Fate of Pre-neoplastic Cells in a Mouse Model of Medulloblastoma
(2009)Studying the early stages of cancer can provide important insight into the molecular basis of the disease. In many human cancers, such as prostate, pancreatic, and colon cancer, a pre-neoplastic, or intermediate, stage of ... -
Molecular variants and mutations in medulloblastoma.
(Pharmgenomics Pers Med, 2014)Medulloblastoma is the commonest malignant brain tumor in children. Treatment with surgery, irradiation, and chemotherapy has improved outcomes in recent years, but patients are frequently left with devastating neurocognitive ... -
The Role of FGF Signaling During Granule Neuron Precursor Development and Tumorigenesis
(2010)Development requires a delicate balance of proliferation and differentiation. Too little proliferation can result in dysfunctional tissues, while prolonged or heightened proliferation can result in tumor formation. This ... -
Understanding the Cellular Response to Cytosolic Cytochrome c
(2010)Cytosolic cytochrome c promotes apoptosis by triggering caspase activation. In healthy cells cytochrome c localizes to mitochondria, where it participates in the electron transport chain. Apoptotic stimuli induce permeabilization ...
