Browsing by Subject "metabolism"
Now showing items 1-20 of 28
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3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.
(Matrix biology : journal of the International Society for Matrix Biology, 2022-06-04)Pulmonary hypertension (PH) comprises a diverse group of disorders that share a common pathway of pulmonary vascular remodeling leading to right ventricular failure. Development of anti-remodeling strategies is an emerging ... -
A tale of two metallophosphatases: biochemical and functional characterization of novel substrates of PP1 and MESH1
(2017)Addition and removal of phosphate is an important post-translational modification involved in cellular signaling. The enzymes responsible for removing this phosphorylation mark, called phosphatases, play a vital role in ... -
Autophagy in Metabolism, Cell Death, and Leukemogenesis
(2011)Tissue homeostasis is controlled by the availability of growth factors, which sustain exogenous nutrient uptake and prevent apoptosis. Cancer cells, however, can express constitutively active oncogenic kinases such as BCR-Abl ... -
Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.
(Journal of the American Geriatrics Society, 2018-05-08)To determine whether combinations of inflammatory markers are related to physical function.secondary analysis of baseline of three observational studies of community-dwelling older adults MEASUREMENTS: The baseline data ... -
Exploiting Metabolic Vulnerabilities In Solid Tumors Treated With ABL Kinase Allosteric Inhibitors
(2021)Metastases are common and devastating complications linked to ~90% of cancer deaths. Therapy-resistance is a major challenge for the treatment of cancer cell metastasis as metastatic cells metabolically rewire to survive ... -
Exploring the Role of Mitochondrial Bioenergetics and Metabolism in Heart Failure
(2020)Heart failure is a worldwide public health problem with substantial clinical burden and economic costs. In the progression into failure, the heart undergoes dramatic alterations in mitochondrial fuel metabolism and bioenergetics. ... -
Genomic Basis for a Developmental Life History Switch in the Sea Urchin Heliocidaris erythrogramma
(2021)Lecithotrophic (non-feeding) larval development has independently evolved numerous times in marine invertebrates from an ancestral, planktotrophic (feeding) larval state. The evolution of this developmental mode in a species ... -
Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.
(Aging (Albany NY), 2017-03-04)Recent research has proposed that GIT2 (G protein-coupled receptor kinase interacting protein 2) acts as an integrator of the aging process through regulation of 'neurometabolic' integrity. One of the commonly accepted hallmarks ... -
GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.
(Front Endocrinol (Lausanne), 2015)Aging represents one of the most complicated and highly integrated somatic processes. Healthy aging is suggested to rely upon the coherent regulation of hormonal and neuronal communication between the central nervous system ... -
Glucose metabolism and p53 in leukemia
(2011)Healthy cells require input from growth factor signaling pathways to maintain cell metabolism and survival. Growth factor deprivation induces a loss of glucose metabolism that contributes to cell death in this context, ... -
Glutaminase Modulates T Cell Metabolism and Function in Inflammation and Cancer
(2018)During the immune response, helper T cells must proliferate and upregulate key metabolic programs including glucose and glutamine uptake. Metabolic reprogramming is imperative for appropriate T cell responses, as inhibition ... -
Harnessing Optical Imaging for Assessing Metabolic Reprogramming in Breast Cancer
(2020)According to the World Health Organization, there were over 2 million new breast cancer cases in 2018. This number is projected to steadily increase year after year. American Cancer Society projections for 2020 list the ... -
Investigating the Metabolic Reprogramming of Ovarian Cancer
(2023)Ovarian cancer (OC) is the most lethal gynecological malignancy, with aggressive metastatic disease responsible for the majority of ovarian cancer related deaths. Despite the clinical significance of OC omental metastases, ... -
Leveraging Complementary In Vivo and In Vitro Gene Expression Measurements to Elucidate Uniquely Human Metabolic Processes
(2012)The origin of man has motivated researchers to investigate differences between humans and our non-human relatives. The striking phenotypic differences that distinguish humans from chimpanzees are likely controlled by a ... -
Linking Urban Land Use to Aquatic Metabolic Regimes
(2021-04-30)Metabolism is a foundational property of ecosystems, and the productivity of rivers determines their capacity to retain and transform nutrients as well as support biodiversity. Stream metabolism has been increasingly used ... -
Linking Urban Land Use to Aquatic Metabolic Regimes
(2021-04-30)Metabolism is a foundational property of ecosystems, and the productivity of rivers determines their capacity to retain and transform nutrients as well as support biodiversity. Stream metabolism has been increasingly used ... -
Metabolic Changes with Base-Loading in CKD.
(Clinical journal of the American Society of Nephrology : CJASN, 2018-06-22) -
Metabolic Control of CaMKII-mediated Caspase-2 Suppression by B55β/PP2A
(2015)Apoptosis is a programmed form of cell death, essential for maintaining tissue homeostasis and eliminating dysfunctional cells. The process of apoptosis is executed by a family of cysteine proteases called caspases. High ... -
Metabolic Targeting of Cancer Cells: Two Molecular Mechanisms Involving Glucose Metabolism
(2009)Selective therapeutic targeting of tumors requires identification of differences between the homeostatic requirements of cancer and host cells. One such difference is the manner in which cancer cells acquire energy. Cancer ... -
Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure.
(J Am Heart Assoc, 2016-07-29)BACKGROUND: Metabolic impairment is an important contributor to heart failure (HF) pathogenesis and progression. Dysregulated metabolic pathways remain poorly characterized in patients with HF and preserved ejection fraction ...
