Now showing items 1-5 of 5

    • A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division. 

      Wang, Lihua; Bu, Pengcheng; Ai, Yiwei; Srinivasan, Tara; Chen, Huanhuan Joyce; Xiang, Kun; Lipkin, Steven M; ... (8 authors) (Elife, 2016-04-14)
      The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here ...
    • Context dependent substitution biases vary within the human genome 

      Nevarez, P Andrew; DeBoever, Christopher M; Freeland, Benjamin J; Quitt, Marissa A; Bush, Eliot C (2010)
      Background: Models of sequence evolution typically assume that different nucleotide positions evolve independently. This assumption is widely appreciated to be an over-simplification. The best known violations involve biases ...
    • IDH1 R132H Mutations Actively Contribute to the Epigenetic State of Glioma Cells 

      Moure, Casey Joseph (2019)
      Point mutations in the active site of isocitrate dehydrogenases 1 and 2 (\textit{IDH}) occur in the majority of WHO grade II and III gliomas, resulting in a unique milieu of signaling and metabolism. IDH1/2 active site ...
    • Molecular Characterization of Genetic and Epigenetic Alterations in Gliomas 

      Duncan, Christopher Gentry (2012)
      Glioma development and progression are driven by complex genetic alterations, including point mutations and gain or loss of genomic copy number, as well as epigenetic aberrations, including DNA methylation and histone ...
    • Variable histone modifications at the A(vy) metastable epiallele 

      Dolinoy, Dana C; Weinhouse, Caren; Jones, Tamara R; Rozek, Laura S; Jirtle, Randy L (2010)
      The ability of environmental factors to shape health and disease involves epigenetic mechanisms that mediate gene-environment interactions. Metastable epiallele genes are variably expressed in genetically identical individuals ...