Browsing by Subject "miRNA"
Now showing items 1-9 of 9
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Creation of Versatile Cloning Platforms for Transgene Expression and Epigenome Editing and Their Application to Pancreatic Islet Biology
(2018)Insulin secreting β-cells within the pancreatic islets of Langerhans are vital to maintaining glycemic control. β-cell functional mass is lost during the progression to both Type 1 and Type 2 diabetes mellitus, resulting ... -
MicroRNA Function in Cellular Stress Response
(2012)MicroRNAs are key post-transcriptional regulators that have been found to play critical roles in the regulation of cellular functions. There is an emerging concept that microRNAs may be just as essential for fine-tuning ... -
MicroRNA Target Prediction via Duplex Formation Features and Direct Binding Evidence
(2012)MicroRNAs (miRNAs) are small RNAs that have important roles in post-transcriptional gene regulation in a wide range of species. This regulation is controlled by having miRNAs directly bind to a target messenger RNA (mRNA), ... -
MicroRNA-29 is an essential regulator of brain maturation through regulation of CH methylation.
(Cell reports, 2021-04)Although embryonic brain development and neurodegeneration have received considerable attention, the events that govern postnatal brain maturation are less understood. Here, we identify the miR-29 family to be strikingly ... -
Molecular Insights of CD4+ T Cell Differentiation, Effector Formation and Helper Function
(2016)CD4+ T cells play a crucial in the adaptive immune system. They function as the central hub to orchestrate the rest of immunity: CD4+ T cells are essential governing machinery in antibacterial and antiviral responses by ... -
Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma.
(Int J Cancer, 2015-10-01)The early detection of hepatocellular carcinoma (HCC) presents a challenge because of the lack of specific biomarkers. Serum/plasma microRNAs (miRNAs) can discriminate HCC patients from controls. We aimed to identify and ... -
Principles of HuR-RNA targeting, interaction dynamics, and functional outcomes
(2010)In recent years, the pervasiveness and importance of post-transcriptional regulation has reshaped the underlying principles of the organizational logic of gene expression. RNA-binding proteins (RBPs) and non-coding RNAs ... -
Sequencing and characterization of non-coding small RNAs controlling development in Arabidopsis thaliana roots
(2011)Small noncoding RNAs (ncRNAs) are key regulators of plant development through modulation of the processing, stability and translation of larger RNAs. I generated small RNA datasets comprising over 200 million aligned Illumina ... -
The Role of Erythrocytic miRNA in the lifecycle of Plasmodium falciparum
(2012)Malaria, caused by the apicomplexan parasite Plasmodium, is a disease which affects up to 500 million people each year. Historically, malaria infection has been combated both through the control of its vector, the Anopheles ...
