Browsing by Subject "microRNA"
Now showing items 1-15 of 15
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A Genetic Analysis of the MicroRNA miR-133b in the Mammalian Nervous System
(2011)The development and function of the nervous system relies on complex regulation of gene expression programs. MicroRNAs (miRNAs) are small RNAs that have diverse functions in mammalian development and disease. In concert ... -
EBV BART MicroRNAs Target Pro-apoptotic and Anti-Wnt Signaling Genes to Promote Cell Survival and Proliferation
(2015)Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus which chronically infects >95% of the global population, and can give rise to a number of malignancies in B cells and epithelial cells. In EBV latently infected ... -
Identifying Critical Biological Effectors in Glioma Initiating Cells
(2012)Glioblastoma (GBM) represents the most common and lethal brain tumor in adults, with glioma initiating cells (GICs) implicated to play a critical role in its progression and recurrence. However, the molecular mechanisms ... -
Integrative Analysis of the Myc and E2F pathway Reveal the Roles for microRNAs in Cell Fate Control
(2011)Cancer is a disease state that arises as a result of multiple alterations in signaling pathways that are critical for making key cell fate decisions in normal cells. Understanding how these pathways operate under normal ... -
Interactions of Mammalian Retroviruses with Cellular MicroRNA Biogenesis and Effector Pathways
(2014)The cellular microRNA (miRNA) pathway has emerged as an important regulator of host-virus interactions. While miRNAs of viral and cellular origin have been demonstrated to modulate viral gene expression and host immune ... -
MicroRNA and Epigenetic Controls of CD4+ T cells' Activation, Differentiation and Maintenance
(2014)As a major component of the adaptive immune system, CD4+ T cells play a vital role in host defense and immune tolerance. The potency and accuracy of CD4+ T cell-mediated protection lie in their ability to differentiate into ... -
MicroRNA Function in Cellular Stress Response
(2012)MicroRNAs are key post-transcriptional regulators that have been found to play critical roles in the regulation of cellular functions. There is an emerging concept that microRNAs may be just as essential for fine-tuning ... -
microRNA Regulation of Cellular Immunity
(2016)Immunity is broadly defined as a mechanism of protection against non-self entities, a process which must be sufficiently robust to both eliminate the initial foreign body and then be maintained over the life of the host. ... -
Plasmonic Nanoplatforms for Sensing, Diagnostics, and Therapy
(2020)Recent advances in nanotechnology have led to the application of nanoparticles in a wide variety of fields. In particular, anisotropic nanoparticles have shown great potential for surface-enhanced Raman scattering (SERS) ... -
Polymorphisms at the microRNA binding-site of the stem cell marker gene CD133 modify susceptibility to and survival of gastric cancer.
(Mol Carcinog, 2015-06)CD133 is one of the most common stem cell markers, and functional single nucleotide polymorphisms (SNPs) of CD133 may modulate its gene functions and thus cancer risk and patient survival. We hypothesized that potentially ... -
Role of MicroRNAs in Human Skeletal Muscle Tissue Engineering In Vitro
(2014)The development of a functional tissue-engineered human skeletal muscle model in vitro would provide an excellent platform on which to study the process of myogenesis, various musculoskeletal disease states, and drugs and ... -
SR proteins in microRNA/mRNA biogenesis
(2011)SR proteins are a family of splicing factors involved in the regulation of both constitutive and alternative splicing of pre-mRNAs. Despite years of studies, several big questions still remain: how the expression levels ... -
Targeting T Cells for the Immune-Modulation of Human Diseases
(2015)Dysregulated inflammation underlies the pathogenesis of a myriad of human diseases ranging from cancer to autoimmunity. As coordinators, executers and sentinels of host immunity, T cells represent a compelling target population ... -
The Role of miR-126/126* in Microenvironmental Regulation of Cancer Metastasis
(2013)Cancer metastasis is the cause of about 90% of cancer patients' deaths. Despite significant improvements in the past three decades in understanding the molecular bases of oncogenic transformation of cancer cells, little ... -
The role of poly(A)-binding protein in microRNA-mediated repression
(2010)microRNAs (miRNAs) downregulate the expression of numerous mRNAs and are involved in almost every biological process where they have been examined. Inherent sequence or cis-elements located in mRNA termini and 5' and 3' ...
