Browsing by Subject "neurodegeneration"
Now showing items 1-6 of 6
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Effects of mitochondrial dynamics genes, fzo-1 and drp-1, on dopaminergic neurodegeneration induced by environmental exposure in Caenorhabditis elegans, as a model of Parkinson’s disease
(2015-05-30)Parkinson’s disease (PD) is caused by degeneration of the dopaminergic neurons; environmental toxicants are hypothesized to play a role in PD etiology. Environmental toxicants can cause mitochondrial dysfunction through ... -
Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases.
(Rare Dis, 2014)Non-cell autonomous degeneration has arisen as an important mechanism in neurodegenerative disorders. Using a novel line of BAC androgen receptor (AR) transgenic mice with a floxed transgene (BAC fxAR121), we uncovered a ... -
Non-Dopaminergic Motor Control: an Investigation of Serotonergic Circuitry in Parkinson’s Disease
(2018)The loss of nigrostriatal dopaminergic neurons is the fundamental hallmark of Parkinson’s disease (PD). In early PD stages, this is ameliorated by dopamine (DA) supplementation; however, as the disease progresses, the complete ... -
Survey of quality of life, phenotypic expression, and response to treatment in Krabbe leukodystrophy.
(JIMD reports, 2019-05)<h4>Objectives</h4>To develop a quality of life (QOL) survey for Krabbe disease (KD), and to thereby improve understanding of its phenotypic expression and response to treatment.<h4>Methods</h4>The survey, the Leukodystrophy ... -
The Regulation of Lipid Metabolism and Mitochondrial Quality Control in Health and Disease
(2015)Advances in modern medicine have helped to prolong human life. These advancements coupled with an ever-increasing population means that diseases associated with aging will become more prevalent in the coming years. As ... -
Toxicant-Induced Mitochondrial Dysfunction and Dopaminergic Neurodegeneration in Caenorhabditis elegans
(2017)Mitochondrial dysfunction appears to be a hallmark of many neurodegenerative diseases. The link between mitochondrial and neuronal health is particularly strong in Parkinson’s disease (PD). Genes that have been shown to ...
