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Browsing by Subject "oxidative stress"
Now showing items 1-17 of 17
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A Tissue-Engineered Blood Vessel Model for Vascular Aging
(2021)Clinical studies have identified strong correlations between aging and the development of atherosclerosis. In particular, endothelial cell senescence is implicated in age-related changes in vasoreactivity. Oxidative stress ... -
Biomonitoring of Amino-PAHs, Cotinine, and PAH-hemoglobin Adducts in Human Specimens
(2018-04-27)Diesel exhaust is a large source of outdoor air pollution in urban area, while smoking is an important contributor to indoor air pollution in our daily life. Exposure to these complex mixtures may lead to many adverse health ... -
Development of Fluorescent Iron and Copper Sensors Activated by Hydrogen Peroxide or Ultraviolet Light
(2011)Fluorescent sensors provide a powerful analytical tool for the intracellular detection of metal cations. In some cases, these fluorescent metal-chelating sensors have helped elucidate the function of metal cations within ... -
Development of Stimulus-Responsive Ligands for the Modulation of Copper and Iron Coordination
(2014)The ability to manipulate the coordination chemistry of metal ions has significant ramifications for the study and treatment of metal-related health concerns, including iron overload, UV skin damage, and microbial infection ... -
Differential Packaging of Outer Membrane Proteins of Enterotoxigenic Escherichia coli into Outer Membrane Vesicles under Oxidative Stress Conditions Reveals a Potential Mechanism for Vesicle Cargo Selectivity
(2020)Outer membrane vesicles (OMVs) are spherical structures that bud from the outer membrane (OM) of bacteria containing OM and periplasmic material. They are known to be produced by all bacteria studied to date and play important ... -
Effects of Oxidative Stress on Airway Epithelium Permeability in Asthma and Potential Implications for Patients with Comorbid Obesity.
(Journal of asthma and allergy, 2023-01)20 million adults and 4.2 million children in the United States have asthma, a disease resulting in inflammation and airway obstruction in response to various factors, including allergens and pollutants and nonallergic triggers. ... -
Gene expression in developing fibres of Upland cotton (Gossypium hirsutum L.) was massively altered by domestication
(2010)Background: Understanding the evolutionary genetics of modern crop phenotypes has a dual relevance to evolutionary biology and crop improvement. Modern upland cotton (Gossypium hirsutum L.) was developed following thousands ... -
Keap1-Nrf2 Heterodimer: A Therapeutic Target to Ameliorate Sickle Cell Disease.
(Antioxidants (Basel, Switzerland), 2023-03)Sickle cell disease (SCD) is a monogenic inheritable disease characterized by severe anemia, increased hemolysis, and recurrent, painful vaso-occlusive crises due to the polymerization of hemoglobin S (HbS)-generated oxidative ... -
Mechanisms Regulating Pulmonary Sensitivity to Radiation
(2012)At the present time, here is no approved medical countermeasure (MCM) for mitigating or treating pneumonitis/fibrosis following acute radiation exposure. Since it is neither ethical nor feasible to evaluate potential MCMs ... -
Metabolic Regulation of Kelch-like Proteins Through O-glycosylation
(2018)O-GlcNAcylation is a reversible post-translational modification that decorates an O-linked ß-N-acetylglucosamine (O-GlcNAc) moiety onto the serine/threonine residues of target proteins. In mammals, this modification is regulated ... -
Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans
(2010)To define the mechanisms involved in the molecular response to the carcinogenic metal cadmium, two novel metal-inducible genes from C. elegans were characterized: numr-1 and numr-2 (nuclear localized metal responsive). numr-1 ... -
Oxidative Stress and Thrombosis during Aging: The Roles of Oxidative Stress in RBCs in Venous Thrombosis.
(International journal of molecular sciences, 2020-06-15)Mid-life stage adults are at higher risk of developing venous thrombosis (VT)/thromboembolism (VT/E). Aging is characterized by an overproduction of reactive oxygen species (ROS), which could evoke a series of physiological ... -
Redox mechanisms of cardiomyocyte mitochondrial protection.
(Front Physiol, 2015)Oxidative and nitrosative stress are primary contributors to the loss of myocardial tissue in insults ranging from ischemia/reperfusion injury from coronary artery disease and heart transplantation to sepsis-induced myocardial ... -
Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation.
(Nanotoxicology, 2016-11)Silver nanoparticles (AgNPs) have been increasingly commercialized and their release into the environment is imminent. Toxicity of AgNP has been studied with a wide spectrum of organisms, yet the mechanism of toxicity remains ... -
Synthesis and Characterization of Second- Generation Iron Pro-chelators
(2010)Excessive amounts of labile metals such as iron, zinc, and copper have been found in the brains of patients diagnosed with various neurodegenerative diseases, which include Alzheimer's and Parkinson's disease. Iron and ... -
The Toxicological Effects of Engineered Nanoparticles, Quantum Dots, in Estuarine Fish
(2010)Engineered nanoparticles (ENPs) are a part of everyday life. They are incorporated into a wide array of products including sunscreens, clothing, electronics, paints, and automobiles. One particular type of ENP, quantum ... -
Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.
(Hypoxia (Auckland, N.Z.), 2017-01)The "Hypoxia Nantes 2016" organized its second conference dedicated to the field of hypoxia research. This conference focused on "the role of hypoxia under physiological conditions as well as in cancer" and took place in ...
