Browsing by Subject "phosphatase"
Now showing items 1-4 of 4
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A tale of two metallophosphatases: biochemical and functional characterization of novel substrates of PP1 and MESH1
(2017)Addition and removal of phosphate is an important post-translational modification involved in cellular signaling. The enzymes responsible for removing this phosphorylation mark, called phosphatases, play a vital role in ... -
Metabolic Control of CaMKII-mediated Caspase-2 Suppression by B55β/PP2A
(2015)Apoptosis is a programmed form of cell death, essential for maintaining tissue homeostasis and eliminating dysfunctional cells. The process of apoptosis is executed by a family of cysteine proteases called caspases. High ... -
Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells.
(Molecular and cellular biology, 2018-11)While several protein serine/threonine kinases control cytokine production by T cells, the roles of serine/threonine phosphatases are largely unexplored. Here, we analyzed the involvement of protein phosphatase 1α (PP1α) ... -
TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage
(2016)The DNA of a cell operates as its blueprint, providing coded information for the production of the RNA and proteins that allow the cell to function. Cells can face a myriad of insults to their genomic integrity during their ...
