Browsing by Subject "phototransduction"
Now showing items 1-5 of 5
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Photoreceptors in a Mouse Model of Leigh Syndrome are Capable of Normal Light-Evoked Signaling.
(The Journal of biological chemistry, 2019-06-27)Mitochondrial dysfunction is an important cause of heritable vision loss. Mutations affecting mitochondrial bioenergetics may lead to isolated vision loss or life-threatening systemic disease, depending on a mutation's severity. ... -
Temporal resolution of single photon responses in primate rod photoreceptors and limits imposed by cellular noise.
(Journal of neurophysiology, 2018-11-28)Sensory receptor noise corrupts sensory signals, contributing to imperfect perception and dictating central processing strategies. For example, noise in rod phototransduction limits our ability to detect light and minimizing ... -
The Functional and Pathophysiological Consequences of Transducin γ-Subunit Knockout
(2019)The initial steps of vertebrate vision take place in the retina, where light-sensitive rod and cone photoreceptor cells translate light into an electrical signal through a biochemical process called phototransduction. Transducin, ... -
Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors.
(eNeuro, 2018-05)The heterotrimeric G-protein transducin mediates visual signaling in vertebrate photoreceptor cells. Many aspects of the function of transducin were learned from knock-out mice lacking its individual subunits. Of particular ... -
UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling.
(Proc Natl Acad Sci U S A, 2013-08-20)At our body surface, the epidermis absorbs UV radiation. UV overexposure leads to sunburn with tissue injury and pain. To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epithelial skin ...
