Browsing by Subject "polyglutamine"

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Investigating the protein quality control pathways that prevent protein aggregation in the social amoeba Dictyostelium discoideum

Haver, Holly N (2023)

A major hallmark of many neurodegenerative diseases is protein aggregation. Protein aggregation occurs in part due to failure of protein quality control pathways. A better understanding of these pathways ...
Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases.

Cortes, Constanza J; La Spada, Albert R (Rare Dis, 2014)

Non-cell autonomous degeneration has arisen as an important mechanism in neurodegenerative disorders. Using a novel line of BAC androgen receptor (AR) transgenic mice with a floxed transgene (BAC fxAR121), we uncovered a ...