Browsing by Subject "protein"
Now showing items 1-14 of 14
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Analysis and Error Correction in Structures of Macromolecular Interiors and Interfaces
(2009)As of late 2009, the Protein Data Bank (PDB) has grown to contain over 70,000 models. This recent increase in the amount of structural data allows for more extensive explication of the governing principles of macromolecular ... -
Bayesian Structural Phylogenetics
(2013)This thesis concerns the use of protein structure to improve phylogenetic inference. There has been growing interest in phylogenetics as the number of available DNA and protein sequences continues to grow rapidly and demand ... -
Chemical and Physical Analysis of Melanin in Complex Biological Matrices
(2014)Melanin is a ubiquitous biological pigment found in bacteria, fungi, plants, and animals. It has a diverse range of ecological and biochemical functions including display, evasion, photoprotection, detoxification, and metal ... -
Development and Application of a Mass Spectrometry-Based Assay for the High Throughput Analysis of Protein-Ligand Binding
(2009)Many of the biological roles of proteins are modulated through protein-ligand interactions, making proteins important targets for drug therapies and diagnostic imaging probes. The discovery of novel ligands for a protein ... -
Expression, tandem repeat copy number variation and stability of four macrosatellite arrays in the human genome
(2010)Background: Macrosatellites are some of the largest variable number tandem repeats in the human genome, but what role these unusual sequences perform is unknown. Their importance to human health is clearly demonstrated by ... -
Fundamental Mechanisms in the Extreme UV Resistance of Adenovirus
(2009)The adenoviruses are nonenveloped double stranded DNA viruses, which cause enteric dysentary and respiratory infection. Adenovirus has become a focus of the water treatment community because of its apparent resistance to ... -
Mono- or Double-Site Phosphorylation Distinctly Regulates the Proapoptotic Function of Bax
(2010)Bax is the major multidomain proapoptotic molecule that is required for apoptosis. It has been reported that phosphorylation of Bax at serine(S) 163 or S184 activates or inactivates its proapoptotic function, respectively. ... -
Multiscale Simulations of Biomolecules in Condensed Phase: from Solutions to Proteins
(2010)The thesis contains two directions in the simulations of biomolecular systems. The first part (Chapter 2 - Chapter 4) mainly focuses on the simulations of electron transfer processes in condensed phase; the second part (Chapter ... -
Novel Algorithms for Computational Protein Design, with Applications to Enzyme Redesign and Small-Molecule Inhibitor Design
(2009)Computational protein design aims at identifying protein mutations and conformations with desired target properties (such as increased protein stability, switch of substrate specificity, or novel function) from ... -
POEGMAlation – A Next-Generation PEGylation Technology
(2016)The delivery of therapeutic peptides and proteins is often challenged by a short circulation half-life, necessitating frequent injections that limit efficacy, reduce patient compliance and increase treatment cost. The covalent ... -
Poleward Transport of TPX2 in the Mammalian Mitotic Spindle Requires Dynein, Eg5, and Microtubule Flux
(2010)TPX2 is a Ran-regulated spindle assembly factor that is required for kinetochore fiber formation and activation of the mitotic kinase Aurora A. TPX2 is enriched near spindle poles and is required near kinetochores, suggesting ... -
Protein-DNA Binding: Discovering Motifs and Distinguishing Direct from Indirect Interactions
(2009)The initiation of two major processes in the eukaryotic cell, gene transcription and DNA replication, is regulated largely through interactions between proteins or protein complexes and DNA. Although a lot is known about ... -
Quantification of the Binding Properties of Cu2+ to the Amyloid Beta Peptide: Coordination Spheres for Human and Rat Peptides and Implication on Cu2+-Induced Aggregation
(2010)There is no consensus on the coordinating ligands for Cu2+ by A beta. However, the differences in peptide sequence between human and rat have been hypothesized to alter metal ion binding in a manner that alters Cu2+-induced ... -
The tricarboxylic acid cycle in Shewanella oneidensis is independent of Fur and RyhB control
(2010)Background: It is well established in E. coli and Vibrio cholerae that strains harboring mutations in the ferric uptake regulator gene (fur) are unable to utilize tricarboxylic acid (TCA) compounds, due to the down-regulation ...
