Browsing by Subject "protein design"
Now showing items 1-4 of 4
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Computational Molecular Engineering Nucleic Acid Binding Proteins and Enzymes
(2010)Interactions between nucleic acid substrates and the proteins and enzymes that bind and catalyze them are ubiquitous and essential for reading, writing, replicating, repairing, and regulating the genomic code by the proteomic ... -
Computational Protein Design with Ensembles, Flexibility and Mathematical Guarantees, and its Application to Drug Resistance Prediction, and Antibody Design
(2015-01-01)Proteins are involved in all of life's processes and are also responsible for many diseases. Thus, engineering proteins to perform new tasks could revolutionize many areas of biomedical research. One promising technique ... -
Partition function estimation in computational protein design with continuous-label Markov random fields
(2017-05-04)Proteins perform a variety of biological tasks, and drive many of the dynamic processes that make life possible. Computational structure-based protein design (CSPD) involves computing optimal sequences of amino acids with ... -
Using Protein-Likeness to Validate Conformational Alternatives
(2012)Proteins are among the most complex entities known to science. Composed of just 20 fundamental building blocks arranged in simple linear strings, they nonetheless fold into a dizzying array of architectures that carry out ...
