Browsing by Subject "sepsis"
Now showing items 1-6 of 6
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Accelerated Sepsis Diagnosis by Seamless Integration of Nucleic Acid Purification and Detection
(2014)<bold>Background</bold> The diagnosis of sepsis is challenging because the infection can be caused by more than 50 species of pathogens that might exist in the bloodstream in very low concentrations, e.g., less ... -
Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.
(MBio, 2017-10-03)The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of infected host cells and thereby prompts an inflammatory immune ... -
NOS2 Induction and HO-1-Mediated Transcriptional Control in Gram-Negative Peritonitis
(2013)Nitric oxide (NO) is an endogenous gaseous signaling molecule produced by three NO synthase isoforms (NOS1, 2, 3) and important in host defense. The induction of NOS2 during bacterial sepsis is critical for pathogen clearance ... -
Red Blood Cell Deformability, Vasoactive Mediators, and Adhesion.
(Frontiers in physiology, 2019-01)Healthy red blood cells (RBCs) deform readily in response to shear stress in the circulation, facilitating their efficient passage through capillaries. RBCs also export vasoactive mediators in response to deformation and ... -
Sepsis in sub-Saharan Africa: a prospective observational study of clinical characteristics, management, and outcomes for adolescents and adults with sepsis in northern Tanzania
(2020)Background: Sepsis is a leading cause of death and disability globally. Despite a high burden of sepsis in sub-Saharan Africa, clinical data for sepsis in that setting are limited. We sought to describe the clinical ... -
Toll-like Receptor (TLR) Signaling and Differential Activation of PGC Family Genes in a Mouse Model of Staphylococcus aureus Sepsis
(2010)Sepsis is a major cause of morbidity and mortality in the United States, and Staphylococcus aureus (S. aureus) is the bacteria most commonly cultured from septic patients. In severe sepsis, the relationship between the systemic ...
