Browsing by Subject "signaling"
Now showing items 1-13 of 13
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Abl Family Kinases Regulate Endothelial Function
(2013)The vasculature has a crucial function in normal physiology, enabling the transport of oxygen and nutrients to cells throughout the body. In turn, endothelial cells, which form the inner-most lining of blood vessels, are ... -
Ca2+ channel nanodomains boost local Ca2+ amplitude.
(Proc Natl Acad Sci U S A, 2013-09-24)Local Ca(2+) signals through voltage-gated Ca(2+) channels (CaVs) drive synaptic transmission, neural plasticity, and cardiac contraction. Despite the importance of these events, the fundamental relationship between flux ... -
Examining the Effect of the Context of Heat-Labile Enterotoxin Presentation on the Host Immune Response
(2011)Enterotoxigenic Escherichia coli (ETEC), the leading cause of traveler's diarrhea and childhood mortality due to diarrhea in the developing world, has been shown to secrete heat-labile enterotoxin (LT) in association with ... -
New Insights into GPCR–Transducer Coupling
(2018)β-arrestins (βarrs) interact with G protein-coupled receptors (GPCRs) to desensitize G protein signaling, initiate signaling on their own, and mediate receptor endocytosis. Using a panel of GPCRs believed to couple differently ... -
Nutritional Control of L1 Arrest and Recovery in Caenorhabditis elegans by Insulin-like Peptides and Signaling
(2014)Animals must coordinate development with fluctuating nutrient availability. Nutrient availability governs post-embryonic development in Caenorhabditis elegans: larvae that hatch in the absence of food do not initiate ... -
Phosphorylation of Human Tristetraprolin in Response to Its Interaction with the CbI Interacting Protein CIN85
(2010)Background: Tristetraprolin (TTP) is the prototype member of a family of CCCH tandem zinc finger proteins and is considered to be an anti-inflammatory protein in mammals. TTP plays a critical role in the decay of tumor necrosis ... -
Revealing Asset Quality: Liquidity Signaling and Optimal Stress Tests
(2015)In my first chapter, I present a model in which sellers can signal the quality of an asset both by retaining a fraction of the asset and by choosing the liquidity of the market in which they search for buyers. Although ... -
Sex in Cryptococcus: Signaling, Mating-type Locus Evolution and Gene Silencing
(2008-02-26)Fungi have a genetically controlled sex determination system, which is governed by a small, sex-specific region in the genome called the mating-type locus (MAT). In the basidiomycetous yeast Cryptococcus neoformans, the ... -
Short-Range Inter-Blastomere Signaling Specifies Ectodermal Fate and is Required for Skeletal Patterning in the Sea Urchin
(2012)Sea urchin larvae possess a beautiful, intricately patterned, calcium-carbonate skeleton. Formation of this complex structure results from two independent processes within the developing embryo: specification of the mesenchymal ... -
Sounds of senescence: Male swamp sparrows respond less aggressively to the songs of older individuals
(Behavioral Ecology, 2021-01-01)Age-related changes in assessment signals occur in a diverse array of animals, including humans. Age-related decline in vocal quality in humans is known to affect perceived attractiveness by potential mates and voters, but ... -
The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-Component and Metazoan-Type Tyrosine Kinase Signaling.
(Genome Biol Evol, 2015-11-27)Physarum polycephalum is a well-studied microbial eukaryote with unique experimental attributes relative to other experimental model organisms. It has a sophisticated life cycle with several distinct stages including amoebal, ... -
The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
(2016)Neuroblastoma is a pediatric cancer arising from undifferentiated neural crest-derived precursor cells. Treatment strategies for neuroblastoma aim to promote neuroblast differentiation, however current therapies available ... -
Tough Talk, Cheap Talk, and Babbling: Government Unity, Hawkishness and Military Challenges
(2008-10-23)A number of puzzles exist regarding the role of domestic politics in the likelihood of international conflict. In particular, the sources of incomplete information remain under-theorized and the microfoundations deficient. ...
