ALERT: This system is being upgraded on Tuesday December 12. It will not be available for use for several hours that day while the upgrade is in progress. Deposits to DukeSpace will be disabled on Monday December 11, so no new items are to be added to the repository while the upgrade is in progress. Everything should be back to normal by the end of day, December 12.
Browsing by Subject "small molecule"
Now showing items 1-2 of 2
!Development of small molecule therapeutics against anti-infectious and anti-cancer drug resistance via structure-based drug design (2022)!Drug discovery typically involves structure-based drug design based on three-dimensional protein structures and hit/lead compound identification and optimization. Herein, this technique was used to overcome several obstacles ...
Insights, Assays, and Strategies for Small Molecule-Based Modulation of the MALAT1 RNA Triple Helix (2020)Recent discoveries of myriad of endogenous RNA transcripts that do not code for proteins has led to a paradigm shift in our understanding of human biology. As the subsequent “RNA revolution” continues to elucidate ...