Browsing by Subject "stem cells"
Now showing items 1-8 of 8
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A long non-coding RNA targets microRNA miR-34a to regulate colon cancer stem cell asymmetric division.
(Elife, 2016-04-14)The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here ... -
An Induced Pluripotent Stem Cell-derived Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome for Disease Modeling and Drug Testing
(2018)Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary causes of death are stroke and cardiovascular ... -
Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells
(Advanced Therapeutics, 2019-10-01)Bone marrow stem cells (BMSCs) are a promising strategy for cardiac regenerative therapy for myocardial infarction (MI). However, cell transplantation has to overcome a number of hurdles, such as cell quality control, clinical ... -
Direct Differentiation of Mouse Induced Pluripotent Stem Cells into Nucleus Pulposus-Like Cells
(2012)The intervertebral discs (IVD) contribute to structural stability of the spinal column, attenuate the impact of compressive loads, and enable a wide spectrum of motions. As a consequence of aging, the majority of the adult ... -
Functional Tissue Engineering of Cartilage Using Adipose-derived Stem Cells
(2008-03-31)Articular cartilage is the thin, load-bearing connective tissue that lines the ends of long bones in diarthroidal joints, providing predominantly a mechanical function. Because cartilage is avascular and aneural, it has ... -
Molecular Mechanisms of Airway Epithelial Progenitor Cell Maintenance and Repair.
(2016)The lungs are vital organs whose airways are lined with a continuous layer of epithelial cells. Epithelial cells in the distal most part of the lung, the alveolar space, are specialized to facilitate gas exchange. Proximal ... -
Molecular Regulators of Stem Cell Fate and Tumor Development in the Cerebellum
(2014)Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, ... -
Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.
(Elife, 2015-04-01)Heart regeneration is limited in adult mammals but occurs naturally in adult zebrafish through the activation of cardiomyocyte division. Several components of the cardiac injury microenvironment have been identified, yet ...
